时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
As a result, it remains unclear whether previously reported microbial alterations reflect disease-specific signatures or are driven by aging- and adiposity-related confounding.；Addressing this gap is essential to disentangle HFpEF-associated microbial remodeling from background ecological shifts related to host phenotype.；Accordingly, we aimed to characterize taxonomic and functional alterations in the gut microbiome in HFpEF using shotgun metagenomic sequencing and to evaluate their variation across age and obesity strata.
方法
This cross-sectional study included 234 adult participants: 43 healthy controls, 23 individuals with low atherosclerotic risk (LRAS), and 168 patients with coronary heart disease and heart failure with preserved ejection fraction (CHD + HFpEF).；Participants were recruited at the Heart Center of the University Medical Center (Nazarbayev University, Astana, Kazakhstan) between March and December 2024.；The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of the National Laboratory Astana, Nazarbayev University (protocol No. 05-2023, approved 21 November 2023).；Participants in the LRAS group were identified through cardiovascular screening as individuals with a low estimated cardiovascular risk.
核心结论
CON, LRAS, and CHD + HFpEF (<60 years) did not differ by age (p = 0.22).；BMI was strictly below 30 kg/m2 in all participants, albeit with some variation between the groups (p < 0.01).；CRP levels did not differ significantly between groups (p > 0.05). ‖ 结论：These results align with an expanding literature that positions the gut microbiome as a modulator of cardiometabolic physiology and cardiovascular risk (; ).
局限
Nonetheless, it should be noted that groups exhibited significant heterogeneity in multivariate dispersion; thus, it cannot be excluded that beta-diversity differences were driven by differences in variation.；These patterns indicate that the LRAS group occupies a position between controls and CHD + HFpEF along this gradient, but they do not establish causality: microbiome changes could be a cause, a consequence, or a co-evolving feature of cardiometabolic pathology.；These mechanisms may contribute to adverse cardiac remodeling, including myocardial fibrosis, cardiomyocyte hypertrophy, and extracellular matrix remodeling, and may ultimately influence the development and progression of heart f
对本项目的价值
★☆☆☆☆ 菌群是可远程部署、成本最低的干预变量，但因果性与个体化响应仍是主要瓶颈。
全文来源
PMC JATS 全文（正文 27,749 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Gut microbiome taxonomic and functional capacity alterations in CHD and HFpEF.
- 期刊与标识：Front Microbiol · PMID 42947889 · DOI 10.3389/fmicb.2026.1875692
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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