时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
摘要（PubMed 原文节选）
ETHNOPHARMACOLOGICAL RELEVANCE: Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder with limited effective treatments. Dendrobium officinale Kimura & Migo (D. officinale) has been traditionally used for dementia, but its active constituents and mechanisms remain unclear. AIM OF THE STUDY: This study aimed to systematically characterize the chemical constituents of D. officinale extract (DOE) and elucidate its anti-AD mechanisms using an integrated pharmacological strategy. MATERIALS AND METHODS: The chemical composition of DOE was analyzed using UHPLC-Q-TOF/MS combined with feature-based molecular networking (FBMN). Target prediction and pathway analysis were performed us…
对本项目的价值
中等价值：属「营养感知—自噬—蛋白稳态轴」方向；mTOR / 自噬 / 蛋白质稳态栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.2/5（★★☆☆☆）
全文不可及原因
无 PMCID 且 OpenAlex / Unpaywall 未提供可下载 OA PDF
原文题录
- 中文题名：铁皮石斛提取物经 PI3K-AKT-mTOR 与自噬改善阿尔茨海默病：分子网络整合研究
- 英文标题：Dendrobium officinale extract ameliorates Alzheimer's disease by modulating PI3K-AKT-mTOR pathway and autophagy-related processes: An integrated study combining feature-based molecular networking, network pharmacology and multi-omics.
- 期刊与标识：J Ethnopharmacol · PMID 42966516 · DOI 10.1016/j.jep.2026.122588 · EDAT 2026-10-31