时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
摘要（PubMed 原文节选）
Hypoxia, characterized by a deficiency of oxygen, is associated with the progression of various diseases and the formation of solid tumors. Prolonged hypoxia increases mitochondrial viscosity and induces mitochondrial autophagy, making these important biomarkers of hypoxic conditions. Herein, we developed MI-NO2, a dual-responsive fluorescent probe for the simultaneous detection of nitroreductase (NTR) activity and viscosity. Upon enzymatic reduction by NTR, MI-NO2 is converted to MI, resulting in enhanced intramolecular charge transfer (ICT) and a fluorescence turn-on response in the green channel. The sensing mechanism was confirmed by 1H NMR, HR-MS, HPLC, and DFT calculations. In addition…
对本项目的价值
参考价值：属「营养感知—自噬—蛋白稳态轴」方向；线粒体功能与氧化应激栏目可用作本项目文献库与综述素材。 ｜ 价值分 1.9/5（★★☆☆☆）
全文不可及原因
无 PMCID 且 OpenAlex / Unpaywall 未提供可下载 OA PDF
原文题录
- 中文题名：靶向线粒体的双发射探针用于早期非酒精性脂肪肝缺氧标志物成像
- 英文标题：A mitochondria-targeting dual-emissive probe for imaging hypoxia-associated biomarkers in early non-alcoholic fatty liver disease.
- 期刊与标识：Spectrochim Acta A Mol Biomol Spectrosc · PMID 42966253 · DOI 10.1016/j.saa.2026.129049 · EDAT 2026-10-31