时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
研究问题
Most of the previous studies on CMM have focused on European and American populations [ 11 , 12 ], and it is unclear whether the TyG‐WHtR index can be utilized as a reliable predictor of CMM.；This study is a cohort study designed to evaluate the predictive value of TyG‐WHtR as a continuous variable.；Three models have been constructed to investigate the link between TyG‐WHtR and CMM, and included unadjusted crude models (Model 1); adjusted models for age, sex, education, location, and marital status (Model 2); and further adjusted models for smoking status, BMI, and WC (Model 3).
方法
Therefore, using data from CHARLS, a nationally representative cohort of Chinese middle‐aged and older adults, this study may help address the geographical evidence gap and provide population‐specific evidence on the association between TyG‐WHtR and CMM.；This study is a cohort study designed to evaluate the predictive value of TyG‐WHtR as a continuous variable.；2 Methods 2.1 Study Population Our data comes from CHARLS, a nationwide population‐based cohort study.
核心结论
2 Methods 2.1 Study Population Our data comes from CHARLS, a nationwide population‐based cohort study.；We found a nonlinear (U‐shaped) relationship between the TyG‐WHtR index and the risk of CMM.；According to our results, there is a U‐shaped connection between the TyG‐WHtR index and CMM risk, which means that controlling the TyG‐WHtR index within a reasonable range can contribute to decreasing the risk of CMM, and too low or too high a value of TyG‐WHtR can increase the risk of developing CMM.
局限
However, the interaction between TyG‐WHtR and smoking status was not statistically significant (P for interaction = 0.18), suggesting that the association did not statistically differ across smoking subgroups.；Given the lack of detailed information on smoking intensity, time since cessation, reasons for quitting, and post‐cessation weight change, this subgroup finding should be interpreted cautiously.
对本项目的价值
参考价值：属「生物标志物 / 建模方法学」方向；代谢 / 内分泌 / 肝肾老化的界面栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.1/5（★★☆☆☆）
全文来源
PubMed PMC JATS（正文 21,315 字符，题名指纹 1.00，已过 DOI 逐字 + 题名指纹 + 正文长度三重归属校验）
原文题录
- 中文题名：甘油三酯-葡萄糖-腰高比指数与中老年人心血管代谢共病的剂量-反应关系
- 英文标题：Dose-Response Relationship Between Triglyceride Glucose-Waist Height Ratio Index and Cardiometabolic Multimorbidity Among Chinese Middle-Aged and Older People.
- 期刊与标识：J Clin Lab Anal · PMID 42963829 · DOI 10.1002/jcla.70389 · PMC PMC13722822 · EDAT 2026-10-31