时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
研究问题
Whether repeated eGDR measures provide distinct or complementary risk information in MASLD remains insufficiently examined.；We hypothesized that lower cumulative eGDR and longitudinal eGDR patterns characterised by low eGDR at both observed measurements or a marked decline between measurements would be associated with a higher risk of incident CVD.；1 Flow chart of participant selection In addition, we constructed a 2011 baseline supportive cohort to evaluate the association between a single baseline eGDR measurement and long-term CVD risk and to provide complementary evidence that did not require survival to the 2015 landmark or the availability of repeated eGDR measurements.
方法
Methods Study design and population This study used data from the China Health and Retirement Longitudinal Study (CHARLS), a nationally representative longitudinal cohort of community-dwelling adults aged 45 years or older in China.；The national baseline survey was conducted in 2011, with follow-up surveys in 2013, 2015, 2018, and 2020 [ 20 , 21 ].；Although the CHARLS source cohort was designed to be nationally representative, the present analyses were based on a selected analytical subset and did not incorporate survey sampling weights; therefore, the final analytical cohort should not be interpreted as nationally representative.
核心结论
Continuous cumulative TyG, METS-IR, C-reactive protein–triglyceride–glucose index, atherogenic index of plasma, cholesterol–high-density lipoprotein–glucose index, and remnant cholesterol were not significantly associated with incident CVD in the fully adjusted models.；Taken together, these findings suggest that repeated eGDR measurements can provide information on the observed level–change context, but much of the incremental discriminatory information captured by cumulative eGDR overlaps with the most recent eGDR measurement.；Our findings are consistent with this evidence and provide complementary evidence among individuals meeting an operational TyG-WC–based MASLD definition.
局限
How might this study influence clinical practice? eGDR may serve as a simple composite cardiometabolic risk marker, while repeated measurements may help characterise the context of change; however, the clinical value and optimal interval of repeated assessment require further validation.；Because waist circumference, hypertension, and HbA1c are components of eGDR and are also established cardiometabolic risk factors, these measures should be interpreted as related representations of a composite cardiometabolic marker rather than as independent dimensions of insulin resistance.
对本项目的价值
参考价值：属「生物标志物 / 建模方法学」方向；代谢 / 内分泌 / 肝肾老化的界面栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.1/5（★★☆☆☆）
全文来源
PubMed PMC JATS（正文 78,603 字符，题名指纹 1.00，已过 DOI 逐字 + 题名指纹 + 正文长度三重归属校验）
原文题录
- 中文题名：累积估算葡萄糖处置率与 eGDR 纵向轨迹对中老年人心血管病发病的影响
- 英文标题：Cumulative estimated glucose disposal rate and longitudinal eGDR patterns in relation to incident cardiovascular disease among middle-aged and older adults with metabolic dysfunction-associated steatotic liver disease: a prospective cohort study.
- 期刊与标识：Cardiovasc Diabetol · PMID 42966860 · DOI 10.1186/s12933-026-03384-w · PMC PMC13723940 · EDAT 2026-11-01