时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
Cardiac surgery during infancy remains a high-risk setting in which perioperative organ protection is central to postoperative recovery.；We further evaluated dose-response form, explored possible age-related heterogeneity, and assessed whether COP added risk information beyond conventional clinical and perfusion variables.
方法
The study was approved by the Ethics Committee of Fuwai Yunnan Cardiovascular Hospital (approval No. 2023-056-01; October 27, 2023) and was conducted in accordance with the Declaration of Helsinki.；Because this was a retrospective study using de-identified data, the requirement for informed consent was waived by the ethics committee.；This single-center retrospective cohort study consecutively included infants with congenital heart disease who underwent cardiac surgery with cardiopulmonary bypass (CPB) at Fuwai Yunnan Cardiovascular Hospital between May 2020 and September 2022.；Exclusion criteria were emergency surgery, preoperative mechanical ventilation, previous cardiac surgery, and missing data for the primary exposure, particularly the absence of a post-CPB COP measurement.
核心结论
Compared with infants without AKI, those who developed AKI were younger (median, 5.0 vs. 7.0 months; P = 0.001), had longer CPB duration (105 vs. 91 min; P = 0.038), and had higher post-CPB COP (16.3 vs. 15.5 mmHg; P = 0.038).；RACHS-1 score and cross-clamp duration were also higher in the AKI group.；Baseline serum creatinine was lower among infants who subsequently met the AKI criterion (21.3 vs. 24.4 μmol/L; P < 0.001), a difference relevant to interpretation of a creatinine-defined endpoint. ‖ 结论：These observations suggest that the relevant information may lie less in the absolute rise in COP than in the physiologic state present at CPB separation—a state shaped by hemodilution, albumin exposure, ultrafiltration, hemoconcentration, and perfusion.
局限
The joint age-COP GAM surface suggested heterogeneity across infancy, and the largest exploratory subgroup estimate occurred in infants aged 10–12 months.；However, subgroup event counts were limited, confidence intervals were wide, and statistical significance in one age band does not establish absence of association in the others.；Prematurity adds another layer of developmental heterogeneity because interruption of late gestational nephrogenesis may reduce nephron endowment and alter subsequent renal functional reserve ().
对本项目的价值
★☆☆☆☆ 代谢轴既干预敏感性最高，也是老药新用供给最充足的来源。
全文来源
PMC JATS 全文（正文 39,108 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Post-cardiopulmonary bypass colloid osmotic pressure and creatinine-defined acute kidney injury in infants undergoing cardiac surgery: an age-modified association.
- 期刊与标识：Front Pediatr · PMID 42952928 · DOI 10.3389/fped.2026.1929104
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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