时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
Further prospective studies incorporating behavioral and metabolic measures are needed to clarify whether BMI has an independent role in axial elongation during orthokeratology wear.Clinical implications and personalized cut-offsThe baseline thresholds derived from ROC analysis (age 11.5 years, AL 24.33 mm, PD 5.10 mm) offer a practical, evidence-based framework for pre-treatment counseling.
方法
This retrospective study aims to assess the one-year efficacy of Ortho-K in a cohort of myopic children and to systematically investigate key baseline characteristics that influence treatment outcomes.MethodsStudy design and participantsThis retrospective, single-arm, pre-post study included 122 myopic children (244 eyes) who were first fitted with Ortho-K lenses at Jiangyin People’s Hospital between January 2024 and December 2025 and completed a one-year follow-up.；The cohort comprised 62 boys (124 eyes) and 60 girls (120 eyes).；Written informed consent was obtained from all participants and their legal guardians.
核心结论
Children older than the identified threshold of 11.5 years demonstrated significantly slower annual AL elongation.；Finally, the model’s R² of 0.48 indicates that other unmeasured factors (e.g., genetic predisposition, precise outdoor time, near-work parameters, parental myopia) contribute to the variability in response and external validation in independent prospective cohorts will be necessary before these cut-offs can be considered for broader clinical application.；In addition, the independent association between higher baseline BMI and greater axial elongation suggests that broader lifestyle or systemic factors may contribute to variability in treatment outcomes.These findings may provide useful reference points for individualized clinical assessment, helping to inform treatment planning, set realistic expectations, and identify children who may benefit from closer monitoring or additional interventions.
局限
However, significant inter-individual variability in treatment response is observed in clinical practice.；However, our sex-specific findings (male threshold 10.5 years, female 11.5 years) suggest a more nuanced interaction, potentially linked to the differential timing of puberty and associated hormonal changes (e.g., growth hormone, estrogens) which may influence scleral remodeling and ocular growth dynamics [11].；These possible mechanisms remain speculative and were not directly examined in the present study, but may warrant further investigation into potential neuro-endocrine-ocular pathways involved in myopia control.The association between higher baseline myopic SE (greater magnitude) and slower axial elongation during orthokeratology wear (β = 0.226, p = 0.011) is consistent with the proposed optical mechanism of Ortho-K.
对本项目的价值
中等价值：属「衰老机制与老年临床」方向；其他衰老相关栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.6/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 21,132 字符，题名指纹 1.0，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：儿童角膜塑形镜佩戴一年轴向伸长相关的临床结局与基线因素：回顾性研究
- 英文标题：Clinical outcomes and baseline factors associated with one-year axial elongation during orthokeratology wear in children: a retrospective study.
- 期刊与标识：BMC ophthalmology · PMID 42972531 · DOI 10.1186/s12886-026-05167-z · PMC PMC13729486