时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
研究问题
To test whether altering the number of imposed envi- ronmental cycles experienced per unit chronologi- cal time affects health biomarkers and lifespan, we compressed and expanded the photic cycle (T-cycle, combined light:dark length) by~10% relative to the 24-h day.；Whether the number of imposed environmental cycles experienced per unit chronological time influences aging in rodent models remains largely unknown.；Manipulation of circadian patterns via gradual, recurring expansion or contraction of the combined day/night length (photic, or T-cycle) to accelerate or decelerate the number of light:dark cycles and periods experienced during a fixed chronological time has not been evaluated for effects on mortality and longevity in mice.
方法
Mortality was measured daily, and survival was compared by Cox and linear mixed models (LMM).；All mice were group housed (n ≤ 3 mice/ cage) for the duration of the study in standard, ven- tilated mouse cages on an open rack system.；Study design Beginning at 8 weeks of age, the male C57BL/6 J mice were provided free access (ad libitum) to a defined diet based on AIN-93G (65.1% kcal car- bohydrate, 16.4% kcal fat, and 18.8% protein [calo- rie: 3.89 kcal/g]; TestDiet, Richmond, IN, USA, Table S1).
核心结论
（原文未给出可直接抽取的对应表述）
局限
Acrophase out- comes should be interpreted cautiously due to differ- ences in lights-on timing among the T-cycle groups during the defined periods of measure.；However, when additionally adjusting for body GeroScience Vol:.
对本项目的价值
中高价值：属「干预策略与临床转化」方向；代谢 / 内分泌 / 肝肾老化的界面栏目可用作本项目文献库与综述素材。 ｜ 价值分 3.2/5（★★★☆☆）
全文来源
出版商/仓储 OA PDF（正文 62,254 字符，题名指纹 1.00，已过 DOI 逐字 + 题名指纹 + 正文长度三重归属校验）
原文题录
- 中文题名：慢性非 24 小时光暗周期改变雄性小鼠健康期指标，但不改总寿命
- 英文标题：Chronic non-24-h light-dark cycles alter healthspan measures but not overall survival in male C57BL/6 J mice.
- 期刊与标识：Geroscience · PMID 42965645 · DOI 10.1007/s11357-026-02568-2 · EDAT 2026-10-31