时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
摘要（PubMed 原文节选）
Cellular senescence is a biological process characterized by stable cell cycle arrest that contributes to tumor suppression and tissue remodeling but can also promote aging-associated dysfunction when senescent cells persist and accumulate. Senescent cells influence neighboring and distant tissues through the senescence-associated secretory phenotype (SASP), of which extracellular vesicles (EVs) are an increasingly recognized component. This review examines how microRNAs (miRNAs) carried by EVs regulate senescence and ageing. miRNAs are key post-transcriptional regulators of senescence, particularly within the p53/p21Cip1 and p16INK4a/Rb tumor suppressor pathways. Selective sorting into EVs …
对本项目的价值
中等价值：属「衰老细胞清除 / SASP 轴」方向；细胞衰老 / senolytics / SASP栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.6/5（★★★☆☆）
全文不可及原因
无 PMCID 且 OpenAlex / Unpaywall 未提供可下载 OA PDF
原文题录
- 中文题名：载 microRNA 的细胞外囊泡：衰老中的机制与治疗潜力
- 英文标题：microRNA-Loaded Extracellular Vesicles: Mechanisms and Therapeutic Potential in Senescence and Ageing.
- 期刊与标识：Mech Ageing Dev · PMID 42966409 · DOI 10.1016/j.mad.2026.112269 · EDAT 2026-10-31