时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
（原文未给出可直接抽取的对应表述）
方法
We used gut metagenomes spanning 25 NHP species and constructed an integrated gut phage catalogue (IGPC) comprising 11 389 nonredundant phage genomes.；Therefore, understanding gut phage in NHPs can enable the utilization of NHPs as ideal research models for phage therapy in human gut diseases.With the rapid development of high-throughput sequencing, numerous novel phage genomes have been retrieved from metagenomic datasets covering various environments, such as soil, lake, ocean and animal gut [11].；However, a comprehensive genome-resolved catalogue of gut phages across different NHPs, enabling detailed functional profiling and large-scale evolutionary comparison with humans, is still lacking.Consequently, we analysed 454 metagenomes from 25 NHP species to characterize gut phage in NHPs and present an integrated gut phage catalogue (IGPC) comprising 11 389 nonredundant phage genomes.
核心结论
Our results suggest that host clade, dietary niche, and lifestyle significantly influence the diversity, composition and function of NHP gut phage. crAss-like phage between NHPs and humans exhibit distinct evolutionary differences.；Amato et al. [13] demonstrated that the gut microbial composition and function of NHPs were more strongly influenced by host clades (at superfamily level or higher taxonomic ranks) than by host dietary niche.；Additionally, we found that the dietary effect on the gut phageome appeared to be secondary to host phylogeny.
局限
Gut phage are recognized as critical modulators of gut microbial communities; however, comprehensive insight into gut phage of NHPs is lacking.；The vast majority of animal gut microbial studies have focused on bacteria because of their greater culturability and well established databases; however, phage (prokaryotic viruses) are increasingly recognized to play a non-negligible role in animal guts.；However, a comprehensive genome-resolved catalogue of gut phages across different NHPs, enabling detailed functional profiling and large-scale evolutionary comparison with humans, is still lacking.Consequently, we analysed 454 metagenomes from 25 NHP species to characterize gut phage in NHPs and present an integrated gut phage catalogue (IGPC) comprising 11 389 nonredundant phage genomes.
对本项目的价值
中等价值：属「代谢 / 内分泌 / 肝肾老化」方向；代谢 / 内分泌 / 肝肾老化的界面栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.9/5（★★★☆☆）
全文来源
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原文题录
- 中文题名：非人灵长类整合肠道噬菌体目录揭示对宿主生态的功能适应及与人类的演化关联
- 英文标题：An integrated gut phage catalogue of nonhuman primates reveals functional adaptation to host ecology and evolutionary link to humans.
- 期刊与标识：Proceedings. Biological sciences · PMID 42976950 · DOI 10.1098/rspb.2026.0827