时间标签:数据日期 2026-11-05 · 生成时间 2026-11-05 05:30(Asia/Shanghai)| 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 | 情报发生日期 2026-11-05
证据级别:摘要级。本条依据 PubMed 结构化摘要与元数据撰写,付费墙全文未获取、未逐节核验,本站未做任何数值推算补全。
摘要(PubMed 原文节选)
Innate immunity detects misplaced nucleic acids arising from infections, tissue damage, or genomic instability, thereby activating interferon and inflammatory gene programmes. The cGAS-STING axis is a core part of this response: DNA-activated cGAS generates 2'3'-cGAMP and engages ER-resident STING to drive TBK1-IRF3 and NF-κB signalling c…
对本项目的价值
参考价值:属「营养感知—自噬—蛋白稳态轴」方向;mTOR / 自噬 / 蛋白质稳态栏目可用作本项目文献库与综述素材。 | 价值分 1.8/5(★★☆☆☆)
全文不可及原因
无 PMCID 且 Europe PMC / OpenAlex / Unpaywall 未提供可下载 OA 全文
原文题录
- 中文题名:cGAS-STING 三元框架:干扰素介导防御、DAMP 驱动炎症与影响肿瘤微环境免疫的信号动力学
- 英文标题:cGAS-STING tripartite framework of interferon-mediated defence, DAMP-driven inflammation, and signalling kinetics influencing tumour microenvironment immunity.
- 期刊与标识:International immunopharmacology · PMID 42976743 · DOI 10.1016/j.intimp.2026.117619