时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
Exercise preconditioning, supported by the concept of muscle memory [21], has emerged as an area of increased interest but of course this is also limited in application if injury or periods of unloading are not predictable.Our laboratory recently examined whether previous resistance training (RT) history influences skeletal muscle responses to disuse with leg brace immobilization followed by recovery RT [22], reporting trained (T) and untrained (UT) participants exhibited divergent muscle mass responses to disuse and recovery RT.；We hypothesized this approach would capture novel temporal molecular changes that are associated with the observed phenotypes, thus generating targets for future research.
方法
Exercise preconditioning, supported by the concept of muscle memory [21], has emerged as an area of increased interest but of course this is also limited in application if injury or periods of unloading are not predictable.Our laboratory recently examined whether previous resistance training (RT) history influences skeletal muscle responses to disuse with leg brace immobilization followed by recovery RT [22], reporting trained (T) and untrained (UT) participants exhibited divergent muscle mass responses to disuse and recovery RT.；Specifically, T participants lost ~ 11% muscle size and UT participants lost ~ 5% muscle size with disuse, while T returned to baseline muscle size and UT gained ~ 18% muscle size (from baseline) with recovery RT.；We posited that the targeted assessments of these markers may not fully capture the molecular complexity underlying the observed phenotypes.
核心结论
Nutritional and pharmacological interventions demonstrate limited efficacy [19, 20].；This method has been demonstrated to be both effective and reliable for small sample sizes [51, 52].；Violin plots showing the changes in RNAs favoring UT at baseline (negative Log2FC, Fig. 2D) and favoring T at baseline (positive Log2FC, Fig. 2E) are presented to demonstrate the convergence of molecular signatures with disuse and recovery RT.
局限
Electrical stimulation-induced muscle contraction conveys modest benefit [12–15]; however, mechanical loading remains the most effective countermeasure [16–18] despite limited feasibility during injury, immobilization, or bed rest.；Critically however, N = 16 (8 UT, 8 T) were included in this analysis, with participants selected based on tissue availability from all three timepoints.；While direct downstream examination of COA8 was not conducted herein, we posit that further research of COA8 in the context of disuse atrophy is warranted.
对本项目的价值
中高价值：属「营养感知—自噬—蛋白稳态轴」方向；mTOR / 自噬 / 蛋白质稳态栏目可用作本项目文献库与综述素材。 ｜ 价值分 3.0/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 51,128 字符，题名指纹 0.81，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：阻力训练者与未训练年轻人骨骼肌对废用及恢复期训练应答的整合多组学分析
- 英文标题：An integrative multi-omic analysis of skeletal muscle in response to disuse and recovery resistance training in resistance trained and untrained young adults.
- 期刊与标识：Skeletal muscle · PMID 42972453 · DOI 10.1186/s13395-026-00440-7 · PMC PMC13729528