时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
Clinical claims should therefore remain tied to the outcome directly measured by each study.Prospective studies that measure microbiome composition (82), ambulatory blood pressure, cerebrovascular function, and cognition in the same participants are needed to determine whether the proposed pathways occur sequentially, independently, or interactively.
方法
The Atherosclerosis Risk in Communities cohort linked midlife hypertension with greater 20-year cognitive decline across multiple cognitive domains (1).；Disruption of this ecosystem, clinically known as gut dysbiosis, has been documented in patients with essential hypertension, coronary artery disease, chronic kidney disease, AD, and VCI.；Throughout this review, “vascular” refers primarily to cerebrovascular injury downstream of hypertension; it is not used as a substitute for the broader spectrum of vascular disease.The emphasis on cerebrovascular consequences reflects the proposed role of hypertension as an intermediate between a gastrointestinal exposure and a cognitive outcome.
核心结论
The gut harbors approximately 38 trillion microorganisms (3) that collectively produce thousands of bioactive metabolites, modulate host immune function, regulate autonomic tone, and maintain barrier integrity.；Li and colleagues (7) demonstrated that hypertensive patients harbor a distinct gut microbiome characterized by reduced microbial diversity, decreased abundance of short-chain-fatty-acid-producing genera (Roseburia, Faecalibacterium prausnitzii, Butyrivibrio), and enrichment of pro-inflammatory taxa, particularly Prevotella and Klebsiella.；Fructooligosaccharides (FOS) have demonstrated direct endothelial function improvements in randomized controlled trial settings (25).3The gut microbiome in cognitive decline3.1Dysbiotic signatures in cognitive decline and dementiaGut microbiome alterations in Alzheimer's disease and vascular cognitive impairment have now been systematically reviewed in multiple studies.
局限
（原文未给出可直接抽取的对应表述）
对本项目的价值
中高价值：属「微生物组及其代谢物干预」方向；微生物组及其代谢物干预栏目可用作本项目文献库与综述素材。 ｜ 价值分 3.1/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 39,650 字符，题名指纹 1.0，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：肠-脑-血管轴：从肠道菌群失调到认知衰退的神经炎症与高血压介导通路汇聚
- 英文标题：The gut-brain-vascular axis: converging neuroinflammatory and hypertension-mediated pathways from gut dysbiosis to cognitive decline.
- 期刊与标识：Frontiers in medicine · PMID 42974330 · DOI 10.3389/fmed.2026.1928026 · PMC PMC13725819