时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
研究问题
In the pre- sent study, we aimed to determine whether chronic alcohol administration alters AhR- and Nrf2-related signaling and whether sesaminol supplementation is associated with an amelioration of any effect.；Gut tissue sections (4-μm thick) were prepared and stained with periodic acid-Schiff (PAS) to evaluate mucosal architecture, and liver sec- tions were similarly processed and stained with Oil Red O to visualize lipid accumulation.；Protein analysis and quantification Western blotting To evaluate colonic protein expression, 100 mg of each tissue sample was lysed in 1 mL of M-PER Mammalian Protein Extraction Reagent (Thermo Fisher Scientific, Waltham, MA, USA) containing a protease inhibitor cocktail (Nacalai Tesque).
方法
Graphical Abstract Keywords Cellular senescence · Alcohol · Sesaminol · Gut microbiota · Aryl hydrocarbon receptor · Nuclear factor erythroid 2-related factor 2 Introduction Data collected globally from diverse cohorts indicate that alcohol use is increasingly prevalent among older adults [1].；In our previous studies of young mice, we established that chronic alcohol intake triggers oxidative stress and inflammation in the gut, resulting in chronic colitis, gut leakiness, and dysbiosis, consistent with a “multi- hit” mechanism for the pathogenesis of alcohol-related colorectal cancer (ARCRC) [10–12].；Experimental groups and housing conditions Young (8 weeks old, n=8) and middle-aged (48 weeks old, n=32) male C57BL/6NCr mice were purchased from SLC (Hamamatsu, Japan).
核心结论
Taken together, these findings suggest that sesaminol may ameliorate the interconnected microbial, metabolic, epithelial, and redox-related responses to chronic alco- hol exposure, thereby attenuating alcohol-associated intestinal dysfunction and senescence-related changes in middle-aged mice.；Furthermore, we demonstrated that oral sesa- minol supplementation ameliorates these patho- physiological changes [11, 12].；These findings indicate that sesaminol supplementation was associated with increased fecal butyrate levels.
局限
However, Group A-ES was character- ized by a restoration of Nrf2 activity to a level com- parable to that of Group A-C (Fig.；However, chronic alcohol administration (Group A-E) resulted in a downward trend in lactate concentrations (Fig.
对本项目的价值
中高价值：属「衰老细胞清除 / SASP 轴」方向；细胞衰老 / senolytics / SASP栏目可用作本项目文献库与综述素材。 ｜ 价值分 3.0/5（★★★☆☆）
全文来源
出版商/仓储 OA PDF（正文 85,569 字符，题名指纹 1.00，已过 DOI 逐字 + 题名指纹 + 正文长度三重归属校验）
原文题录
- 中文题名：芝麻素酚减轻中年小鼠酒精诱导结肠衰老：AhR-Nrf2 轴的可能参与
- 英文标题：Sesaminol attenuates alcohol-induced colonic senescence in middle-aged mice: potential involvement of the AhR-Nrf2 axis.
- 期刊与标识：Geroscience · PMID 42965644 · DOI 10.1007/s11357-026-02622-z · EDAT 2026-10-31