研究进展

衰老生物标志物预测心衰住院后躯体功能与临床结局:REHAB-HF 的启示

来源:J Gerontol A Biol Sci Med Sci · PMID 42968386 · DOI 10.1093/gerona/glag256 · 来源:IMA 知识库《文献层·文献监控卡片》2026-11-03 期 · 摘要级(file_id dGdXdaLpSURA,实际下载核验 387,231 B) · 摘要级,未获取付费墙全文

时间标签:数据日期 2026-11-03 · 生成时间 2026-11-03 05:30(Asia/Shanghai)| 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 | 情报发生日期 2026-11-03

证据级别:摘要级。本条依据 PubMed 结构化摘要与元数据撰写,付费墙全文未获取、未逐节核验,本站未做任何数值推算补全。

摘要(PubMed 原文节选)

BACKGROUND: Acute decompensated heart failure (ADHF) is the most common cause of hospitalization in older adults. Cellular senescence, a hallmark of aging biology, has been implicated in heart failure pathophysiology and functional decline via the pro-inflammatory senescence-associated secretory phenotype (SASP). We evaluated the association between SASP and physical function in older adults hospitalized for ADHF. METHODS: REHAB-HF was a trial of older adults hospitalized for ADHF randomized to a novel physical rehabilitation intervention or attention control. We measured a panel of 18-SASP analytes at in-hospital baseline and at 3-month follow-up. Outcomes included short physical performanc…

对本项目的价值

中高价值:属「衰老细胞清除 / SASP 轴」方向;细胞衰老 / senolytics / SASP栏目可用作本项目文献库与综述素材。 | 价值分 3.5/5(★★★★☆)

全文不可及原因

无 PMCID 且 OpenAlex / Unpaywall 未提供可下载 OA PDF

原文题录

  • 中文题名:衰老生物标志物预测心衰住院后躯体功能与临床结局:REHAB-HF 的启示
  • 英文标题:Senescence Biomarkers Predict Physical Function and Clinical Outcomes After Heart Failure Hospitalization: Insights From REHAB-HF.
  • 期刊与标识:J Gerontol A Biol Sci Med Sci · PMID 42968386 · DOI 10.1093/gerona/glag256 · EDAT 2026-11-02

A 级证据分级:A 级(同行评议人体研究)

本文属人体研究证据,但需注意:观察性或小样本干预的结论不等于已证实临床获益;效应量与长期安全性仍需更大规模、更长随访的试验验证。

关于本文的文献来源:本站依据 IMA 知识库「五刊监控·深度文献卡片」(SOP §4.2 摘要级)撰写,依据期刊公开摘要与 PubMed 元数据;付费墙全文未获取之处已标注「待补全文」,未做任何数值推算补全。