时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
研究问题
A secondary objective was to explore whether serum lipid distributions varied across recorded cataract morphologies.；The separate lipid models were used to reduce the potential effects of correlation among lipid fractions; however, they do not permit determination of whether one lipid fraction is independently associated with cataract after simultaneous adjustment for the other lipid fractions.；Prospective multicentre studies are needed to determine whether serum lipid patterns predict cataract development, progression or subtype.
方法
Korean cohort data implicated low high-density lipoprotein cholesterol (HDL-C), while a review of HDL-C in ocular disease concluded that the direction and magnitude of association vary across populations and cataract subtypes [ 11 , 12 ].；Materials and methods Study design, setting and reporting A hospital-based case-control study was conducted in the Department of Ophthalmology in collaboration with the Department of Biochemistry at Rama Medical College Hospital and Research Centre, Kanpur, Uttar Pradesh, India.；A total of 300 participants were included, comprising 150 cases and 150 controls.
核心结论
Using two-sample Mendelian randomisation, genetically determined primary open-angle glaucoma and myopic refractive error were significantly associated with cataract risk (POAG: OR 1.04, 95% CI 1.01-1.08, P = 0.018; per diopter more hyperopic: OR 0.92, 95% CI 0.89-0.93, P = 6.51 × 10⁻¹³), and this POAG association persisted after adjusting for refractive error.
局限
Clinical evidence, however, is heterogeneous.；The separate lipid models were used to reduce the potential effects of correlation among lipid fractions; however, they do not permit determination of whether one lipid fraction is independently associated with cataract after simultaneous adjustment for the other lipid fractions.
对本项目的价值
参考价值：属「生物标志物 / 建模方法学」方向；代谢 / 内分泌 / 肝肾老化的界面栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.1/5（★★☆☆☆）
全文来源
PubMed PMC JATS（正文 26,157 字符，题名指纹 1.00，已过 DOI 逐字 + 题名指纹 + 正文长度三重归属校验）
原文题录
- 中文题名：血脂异常与年龄相关性白内障：北印度医院病例对照研究
- 英文标题：Serum Lipid Abnormalities and Age-Related Cataract: A Hospital-Based Case-Control Study in North India.
- 期刊与标识：Cureus · PMID 42968867 · DOI 10.7759/cureus.117339 · PMC PMC13723720 · EDAT 2026-11-02