时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
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摘要（PubMed 原文节选）
Alzheimer's disease (AD) is one of the leading causes of dementia worldwide. Its pathological features include Aβ deposition, Tau hyperphosphorylation, and impaired neuronal energy metabolism, accompanied by persistent oxidative stress. As a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, sirtuin 1 (SIRT1) is a central regulator of mitochondrial biogenesis. This review systematically examines the emerging roles of SIRT1 in regulating these pathological processes in AD, with a particular focus on its regulation of mitochondrial biogenesis. It also delineates the complex regulatory mechanisms governing SIRT1, including NAD+-metabolism-dependent regulation, protein interaction-d…
对本项目的价值
中等价值：属「NAD⁺–Sirtuin 代谢轴」方向；线粒体功能与氧化应激栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.6/5（★★★☆☆）
全文不可及原因
标注 OA 但 PDF 下载失败或未通过题名指纹归属校验
原文题录
- 中文题名：阿尔茨海默病中的 SIRT1 信号：线粒体生物发生调控与治疗含义
- 英文标题：SIRT1 Signaling in Alzheimer's Disease: Regulation of Mitochondrial Biogenesis and Therapeutic Implications.
- 期刊与标识：Pharmacol Res · PMID 42966483 · DOI 10.1016/j.phrs.2026.109713 · EDAT 2026-10-31