时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
Although the pathogenesis of PP remains unclear, PP has been increasingly linked to dietary modifications and metabolic dysregulation [,].；However, noninvasive skin imaging techniques such as dermoscopy and RCM may provide valuable adjunctive information for the diagnosis and evaluation of PP.；However, metabolic findings have rarely been analyzed together with dermoscopic, RCM, and histopathological features in case series of PP.
方法
Disease staging was based on the predominant clinical morphology of the representative biopsy-site lesion and its corresponding histopathological findings, according to the criteria proposed by Boer et al.；Dermoscopy and RCM were used as noninvasive adjunctive tools to characterize stage-related imaging features and identify coexisting lesions with features of different stages, but were not included in the formal criteria for patient-level stage assignment.；The included patients had sufficient clinical, histopathological, RCM, dermoscopic, treatment, and follow-up data for analysis; however, some metabolic parameters were incompletely evaluated in selected cases.
核心结论
All patients presented with persistent pruritus and were initially misdiagnosed with eczema or contact dermatitis, demonstrating poor response to conventional anti-allergic therapies.；Based on the predominant findings, cases were classified as early stage (Cases 2, 6, 9), fully developed stage (Cases 1, 3, 4, 7, 8), or late stage (Case 5) ().；In the early stage (n = 3), dermoscopy demonstrated linear vessels on a pinkish background (2/3), a focal honeycomb-like pigment network (2/3), and the absence of significant scales. ‖ 结论：Dermoscopic vascular patterns, including punctate, linear, and reticular vessels, together with pigment networks, correlated histopathologically with perivascular inflammatory infiltrates and pigment redistribution.
局限
Limitations include the small sample size, single-center design, and incomplete standardization of metabolic screening and follow-up testing.
对本项目的价值
★☆☆☆☆ 代谢轴既干预敏感性最高，也是老药新用供给最充足的来源。
全文来源
PMC JATS 全文（正文 18,961 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Clinical, metabolic, dermoscopic, and reflectance confocal microscopy features of prurigo pigmentosa: a retrospective case series.
- 期刊与标识：Ann Med · PMID 42954816 · DOI 10.1080/07853890.2026.2751276
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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