时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
研究问题
Although it is difficult to determine which steps in the neuromuscular pathway contribute to the attenuation in efferent neural drive with advancing age, it is likely, at least in part, due to corticospinal factors since peripheral reflex arc-induced α-motoneuron excitability may appear to exhibit more modest age-related decline (Scaglioni et al.；Initially, the position that elicited the largest M-wave was identified, after which the stimulus intensity was progressively increased by 5–10 mA to determine Mmax.；Simple linear regression analy- ses were performed as exploratory to examine associations between MVC and RFD and the strength determinants.
方法
Total muscle cross-sectional area (CSA) has an estimated annual loss of 0.3–0.5% from the 5th decade (Borkan et Introduction Maximal muscle strength typically declines with 1–2% per year from the fifth decade of life, and this accelerates to ~3% per year from ~70 years of age (Delmonico et al.；There- fore, this cross-sectional study aimed to compare the age- related differences in neural and muscular strength factors in recreationally active old men with young counterparts.；Older participants were recruited through senior society clubs and young controls from a university.
核心结论
Collectively, these findings showed that age-related reductions in muscle strength were accompanied by pronounced alterations in neural function alongside changes in muscle phenotype, despite preserved thigh CSA.；Collectively, in physically active individuals, the results showed that neural and muscle phenotype characteristics were among the age- related differences observed in the present study, despite no significant difference in estimated thigh CSA.；In the current study we show how various neuromuscular components contribute to this decline.
局限
However, the relative contributions of various neuromuscular factors to this decline appear to not be fully understood.；However, maximal muscle strength is lost at a rate 2–5 times higher than muscle mass (Bruce et al.
对本项目的价值
参考价值：属「衰弱 / 肌少症功能结局」方向；其他衰老相关栏目可用作本项目文献库与综述素材。 ｜ 价值分 1.9/5（★★☆☆☆）
全文来源
出版商/仓储 OA PDF（正文 68,263 字符，题名指纹 1.00，已过 DOI 逐字 + 题名指纹 + 正文长度三重归属校验）
原文题录
- 中文题名：休闲活动老年男性力量偏低的神经、收缩与肌肉决定因素
- 英文标题：Neural, contractile, and muscular determinants associated with lower strength in recreationally active older men: a cross-sectional study.
- 期刊与标识：Eur J Appl Physiol · PMID 42965618 · DOI 10.1007/s00421-026-06491-4 · EDAT 2026-10-31