临床试验

紫杉醇涂层球囊 vs 雷帕霉素洗脱支架:小冠脉病变的非劣效随机对照试验

来源:Postepy Kardiol Interwencyjnej · PMID 42965038 · DOI 10.5114/aic.2026.164688 · 来源:IMA 知识库《文献层·文献监控卡片》2026-11-03 期 · 全文级(file_id dGdXdaLpSURA,实际下载核验 387,231 B) · 全文已获取并通过三重归属校验

时间标签:数据日期 2026-11-03 · 生成时间 2026-11-03 05:30(Asia/Shanghai)| 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 | 情报发生日期 2026-11-03

研究问题

Given the limitations of the study, including the limited sample size and asymmetric loss to follow-up, the above findings should be considered exploratory and hypothesis-generating rather than definitive conclusions.

方法

(3) Patients with ≥ 70% diameter stenosis confirmed by quantitative coronary angiography (QCA), with small vessel diameters measuring 2.25–2.75 mm.;Eighteen patients refused angiographic follow-up due to lack of symptoms, financial constraints, or fear of invasive procedures, resulting in a final cohort of 210 patients.;CAG was performed within 24 h before the procedure, immediately post-procedure, and at 6 and 12 months using standardized techniques.

核心结论

These results indicate equivalent performance in lumen diameter improvement and stenosis reduction.;In conclusion, for de novo non-complex small-vessel lesions, DCB met the non-inferiority criterion compared with DES for LLL at 1-year follow-up, without significantly increasing MACE risk.

局限

Bare-metal stents (BMS) initially addressed limitations of balloon angioplasty, particularly acute closure, vascular recoil, and early restenosis [ 3 ].;Despite reducing restenosis and late lumen loss (LLL) in long-term follow-up [ 6 ], contemporary DES exhibit limitations in complex lesions such as small vessel disease (SVD).

对本项目的价值

中高价值:属「营养感知—自噬—蛋白稳态轴」方向;干预策略与临床试验栏目可用作本项目文献库与综述素材。 | 价值分 3.3/5(★★★☆☆)

全文来源

PubMed PMC JATS(正文 34,904 字符,题名指纹 0.95,已过 DOI 逐字 + 题名指纹 + 正文长度三重归属校验)

原文题录

  • 中文题名:紫杉醇涂层球囊 vs 雷帕霉素洗脱支架:小冠脉病变的非劣效随机对照试验
  • 英文标题:Non-inferiority of a paclitaxel-coated balloon versus a rapamycin-eluting metal stent for de novo non-complex small coronary vessel disease: a prospective randomized controlled trial.
  • 期刊与标识:Postepy Kardiol Interwencyjnej · PMID 42965038 · DOI 10.5114/aic.2026.164688 · PMC PMC13721081 · EDAT 2026-10-31

A 级证据分级:A 级(同行评议人体研究)

本文属人体研究证据,但需注意:观察性或小样本干预的结论不等于已证实临床获益;效应量与长期安全性仍需更大规模、更长随访的试验验证。

关于本文的文献来源:本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写,依据已获取的期刊全文(方法、样本量与结论已回到原文核对);未能获取全文的同批条目另行标注「摘要级」,全程未做任何数值推算补全。