时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
This gap in knowledge impedes the development of targeted interventions and therapeutic strategies to effectively treat and prevent this devastating condition.；Previously, kwashiorkor had been attributed to protein deficiency []; however, emerging evidence suggests that its etiology is multifactorial, involving a complex interplay of nutritional, and environmental factors.；However, despite finding aflatoxins in biological samples of children with kwashiorkor [–], a causal link has not be demonstrated as the possibility of reverse causality has not been ruled out [].
方法
Participants were matched by age categories, sex, and triage score as a proxy of clinical severity, with children classified into groups based on edema levels (mild, moderate, and severe), which served as an indicator of kwashiorkor severity (see Table ).；Biological samples were collected at various time points []: upon recruitment for all study participants [], at discharge from inpatient care, and [] at exit from outpatient care (known in this context as an ambulatory therapeutic feeding center, ATFC).；This study recruited children with severe acute malnutrition aged 6 to 59 months eligible for new admission to either inpatient care in the ITFC of the Madarounfa District Hospital or enrolment in outpatient care in one of the ATFC supported by MSF in the region of Madarounfa.
核心结论
NAM children were more likely to test positive for malaria using rapid diagnostic tests compared to children with kwashiorkor or marasmus and they also presented a higher Pediatric Early Warning Scores (PEWS) at baseline.；FA reduced the proteomics data into 9 proteome-LVs (pLV).；Out of 9 pLVs, 7 were found to be different in kwashiorkor (pLV 1, 3, 4, 5 and 7 were higher in kwashiorkor, pLV2 and 9 were lower in kwashiorkor than non-kwashiorkor cases), and hence passed criterion 1. ‖ 结论：These observations suggest that severe malnutrition, and particularly kwashiorkor, is not simply a state of nutrient deficiency but a multifaceted physiological condition that reconfigures systemic molecular interactions.
局限
Previous protein-kinetic studies have demonstrated markedly reduced whole-body protein synthesis in children with kwashiorkor [], making a generalized increase in protein synthesis a less likely explanation, although selective synthesis of individual proteins cannot be excluded.；However, gut microbiome differences between children with kwashiorkor or marasmus and the NAM group cannot be excluded, given the small sample size, similar living conditions, and limited gastroenteritis cases.；Future larger studies are therefore warranted.
对本项目的价值
★☆☆☆☆ 方法学进展决定我们能否在有限样本下检出真实效应，属基础设施级收益。
全文来源
PMC JATS 全文（正文 66,649 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Multi-omics, multi-tissue analysis reveal role of extracellular matrix remodeling and sphingolipid homeostasis in edematous malnutrition (kwashiorkor).
- 期刊与标识：Biomark Res · PMID 42958441 · DOI 10.1186/s40364-026-01016-9
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。