时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
However, the fundamental scientific challenge remains our inability to decipher the preclinical evolution of these tears before they manifest as irreversible structural damage.；Conventional magnetic resonance imaging (MRI) remains the clinical gold standard for assessing meniscal pathology, yet its current utility is largely reactive rather than proactive.；To date, the potential of MRI‐based digital biomarkers to forecast incident degenerative failure within a longitudinal survival framework remains unexplored.
方法
Participants were selected from the publicly available OAI database (, NCT00080171) to construct the Degenerative Meniscus Tears Radiomics (DeMeTeR) cohort (Figure ).；A total of 337 case knees and 337 matched controls were included and randomly divided into development and independent test cohorts (8:2 ratio).；All participants provided informed consent under institutional review board approval.；Data from the OAI cohort included diverse participants, and analyses accounted for sex, race, and age to minimize bias.
核心结论
In the development cohort, no significant differences were found between cases and controls in age, sex, BMI, prior knee injury or surgery, NSAID use, or KOOS scores.；In the test cohort, cases were slightly older (61.5 ± 8.1 vs. 56.4 ± 8.7 years, p < 0.001) and had lower KOOS symptom scores (p = 0.006).；Overall, both cohorts were well balanced, with only NSAID use differing modestly between datasets (8.8% vs. 3.6%, p = 0.043). ‖ 结论：In conclusion, this work establishes a scalable digital framework that extends the role of musculoskeletal imaging from descriptive assessment to prospective risk stratification.
局限
The high‐resolution, isotropic 3D‐DESS sequence played a pivotal role here, allowing the extraction of robust texture and wavelet features that reflect the internal heterogeneity of the tissues [, ].；From a biomechanical perspective, meniscal degeneration may not follow a strictly linear progression.；Several considerations warrant discussion regarding the broader implementation of this framework.
对本项目的价值
★☆☆☆☆ 方法学进展决定我们能否在有限样本下检出真实效应，属基础设施级收益。
全文来源
PMC JATS 全文（正文 40,969 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：A Multi-Structural Radiomic Digital Phenotyping Framework for Deciphering Preclinical Evolution of Degenerative Meniscal Tears.
- 期刊与标识：Adv Sci (Weinh) · PMID 42960748 · DOI 10.1002/advs.78506
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