时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
Such changes are unlikely to be specific to transplantation and may also influence the response of older livers to metabolic overload, ischemia–reperfusion injury, and other acute challenges.；At the molecular level, however, aging is associated with transcriptomic reorganization, altered chromatin accessibility and polymerase pausing, protein-level remodeling, and shifts in lipid and redox metabolism, even when histological change remains subtle (; ; ; ; ).；In practice, these alterations often become most apparent when hepatic reserve is challenged by ischemia–reperfusion, preservation injury, or ex vivo perfusion (; ; ).
方法
This aging-related vulnerability has particular clinical relevance in liver transplantation, where the global shortage of grafts has driven growing reliance on extended-criteria and older donors (; ).；Similar age-related declines in resilience have been documented even in living donor liver transplantation, where using donors aged 50 and older is associated with a 61% increased hazard of graft failure compared with younger cohorts ().；Confidence is strongest when findings converge across layers and, where feasible, are supported by functional assays (; ).
核心结论
Declining mitochondrial metabolic flexibility, impaired quality control, and reduced antioxidant reserve may therefore represent an important biological substrate of age-related hepatic vulnerability (; ).；A recent registry-based analysis of over 111,000 liver transplants reported that significant donor-recipient age mismatches—specifically when older grafts are allocated to younger recipients—were associated with lower 5-year graft survival (69.9%) compared with young-to-old combinations (77.8%) ().；Similar age-related declines in resilience have been documented even in living donor liver transplantation, where using donors aged 50 and older is associated with a 61% increased hazard of graft failure compared with younger cohorts (). ‖ 结论：A module-based interpretation organizes existing omics findings and can guide future studies toward more focused graft assessment, risk-stratification hypotheses, and intervention hypotheses.
局限
A module-based interpretation organizes existing omics findings and can guide future studies toward more focused graft assessment, risk-stratification hypotheses, and intervention hypotheses.
对本项目的价值
★☆☆☆☆ 方法学进展决定我们能否在有限样本下检出真实效应，属基础设施级收益。设计 multi-omics。
全文来源
PMC JATS 全文（正文 43,587 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Multi-omics perspectives on mitochondrial vulnerability in the aging liver: biological modules and translational implications.
- 期刊与标识：Front Cell Dev Biol · PMID 42959209 · DOI 10.3389/fcell.2026.1954948
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