时间标签：数据日期 2026-11-01 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31–2026/11/01 ｜ 情报发生日期 2026-11-01
研究问题
However, the interplay between ubiquitin-dependent and ubiquitin-independent macrolipophagy remains unclear. 3.1.2 Microlipophagy LDs are targeted to lysosomes via macrolipophagy or microlipophagy, which is coordinated by ubiquitination,…；Here we present several classical lipophagy-associated molecules and pathways ( ).
方法
（原文未给出可直接抽取的对应表述）
核心结论
These factors are closely associated with LD catabolism and macrophage lipophagy ( ).；In a rat model of AS with damp-heat syndrome induced by the high-fat diet under high-temperature and high-humidity conditions, berberine intervention increased the expression of LC3II protein, decreased the expression of p62 protein, and reduced the…；Similarly, miR-100 has been shown to stimulate endothelial autophagy through inhibition of mTORC1, leading to reduced NF-κB activity, mitigated vascular inflammation, and decreased atherosclerotic plaque burden ( ).
局限
These three types of lipophagy are not independent but rather interact with one another; however, their interrelationships remain underexplored and warrant further investigation.；However, direct evidence that this herb pair induces macrophage lipophagy remains limited and warrants further investigation.
对本项目的价值
临床前机制证据，需评估物种外推与剂量可行性：营养感知—自噬—蛋白稳态轴决定干预窗口与剂量方案，是组合疗法的时间锚。 ｜ 价值分 1.8/5（★★☆☆☆）
全文来源
PubMed PMC JATS 全文（正文 60,739 字符，已过 DOI 逐字 + 题名指纹双重归属校验）
原文题录
- 英文标题：Macrophage lipophagy in atherosclerosis: from molecular mechanisms to traditional Chinese medicine interventions.
- 期刊与标识：Frontiers in pharmacology · PMID 42959329 · DOI 10.3389/fphar.2026.1916672
B 级证据分级：B 级（同行评议临床前研究，主要为动物模型）
本文核心结论来自动物模型或体外细胞学，属临床前证据，不能外推至人体。「延长健康寿命」「改善功能」等表述在小鼠中的意义，与人类临床结局之间仍有距离。
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