时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
We hypothesize that, following the first year of prolonged hospitalization during the most intense treatment phase, children are exposed to an increasingly active lifestyle, potentially leading to a greater occurrence of post-traumatic fractures in the setting of extensively demineralized bones, despite overall stable LS-BMAD (6).Finally, both TBLH-BMD and LS-BMAD median Z-score levels began to show a progressive recovery from 24 months after diagnosis onward.
方法
However, the mutual influence of the two variables in children treated for ALL has not yet been explored.With the aim of filling these gaps in knowledge, we conducted the present prospective analysis and report the longitudinal trendlines of BMD, circulating mineral and bone turnover markers and BC in children and adolescents during and after treatment of ALL.；Over the first three phases, patients receive intensive chemotherapy schedules and high-dose corticosteroids.；During maintenance, on the other hand, patients are treated with oral methotrexate and 6-mercaptopurine, with no or little impact on hematopoiesis and the immune system.
核心结论
Overall, LS-BMAD was still overtly compromised at T6 (Z-score <−2.0 in 54.8% of patients—Figure 3A).Figure 2The boxplots (panels A, B) show the median and interquartile range of Z-scores of lumbar spine bone mineral apparent density (LS-BMAD Z-score) and the total body less than head bone mineral density (TBLH-BMD Z-score) recorded across the seven sequential timepoints scheduled.；Significant p-values are labeled above connecting brackets, highlighting temporal changes for each marker.Circulating markers of bone formation (i.e., ALP, BAP, and OC) showed a consistent and statistically significant increase over the early treatment phases, with overall stable values during maintenance and after the end of treatment (Figures 5B–D).Focusing on circulating markers of bone resorption, we found a remarkable and prompt increase in β-CTX median values as soon as 6 months after diagnosis, followed by a progressive decline over time (Figure 5E).；Overall, seven patients experienced at least one fracture, and one individual experienced two fractures.
局限
However, the mutual influence of the two variables in children treated for ALL has not yet been explored.With the aim of filling these gaps in knowledge, we conducted the present prospective analysis and report the longitudinal trendlines of BMD, circulating mineral and bone turnover markers and BC in children and adolescents during and after treatment of ALL.；Both malignant cell infiltration and tumor-released cytokines and autocrine factors may potentially affect trabecular bone health, though dedicated studies are warranted to confirm this pathogenic hypothesis (40, 41).；As an increasing wealth of published literature corroborates the mechanistic relationship between LM and BMD (26), these findings led us to speculate that prolonged immobilization and decline in lean body mass may represent key determinants of bone mineral loss among ALL survivors, although further dedicated analyses are warranted to confirm this hypothesis.
对本项目的价值
中等价值：属「衰老机制与老年临床」方向；其他衰老相关栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.6/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 50,589 字符，题名指纹 1.0，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：急性淋巴细胞白血病治疗儿童与青少年骨密度、骨转换标志物与体成分的纵向变化
- 英文标题：Longitudinal changes in bone mineral density, bone turnover markers, and body composition in children and adolescents treated for acute lymphoblastic leukemia.
- 期刊与标识：Frontiers in endocrinology · PMID 42973471 · DOI 10.3389/fendo.2026.1901073 · PMC PMC13724381