时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
However, from a systematic perspective, the focus has been primarily on muscle strength and mass, rather than broader PP factors, such as mobility and functional capacity.；This gap in the literature was a key reason for focusing our investigation on data related to PP.；In this context, this study aimed to comprehensively identify and systematically analyse all the published data on the potential influence that inflammation might exert in PP in particular, as well as to investigate the role of specific inflammation biomarkers (CRP, hs-CRP, IL-6, IL-10, TNFα) in the major PP components.
方法
The exact search equation is included as follows: ((Inflammation[MeSH] OR “C-Reactive Protein“[MeSH] OR CRP OR hs-CRP OR TNFα OR TNF-α OR “Tumor Necrosis Factor-alpha” OR IL-6 OR “interleukin-6” OR IL-10 OR “interleukin-10”) (“physical performance” OR “muscle performance” OR “functional performance” OR “30-s chair stand” OR “30 seconds chair stand” OR “30-s arm curl” OR “30 seconds arm curl” OR “30-s biceps curl” OR “30 seconds biceps curl” OR “gait speed” OR “Timed Up and Go” OR TUG OR “timed up-and-go” OR “sit and reach” OR SPPB) (“community dwelling” OR “community-dwelling” OR “older adult*”)) We included all articles carried out in humans in the English language.；Inclusion and exclusion criteria were defined following the PICOS (population, intervention, comparison, outcome, and study design) criteria as described in Table .
核心结论
A total of 17 articles evidenced a statistically significant influence of inflammation in PP, with one or more inflammation biomarkers investigated (CRP, hs-CRP, IL-6, IL-10, TNFα), whereas 3 articles reported no association (p > 0.05).；On the other hand, higher IL-6 levels were able to detect lower SPPB score in three studies [, , ], followed by CRP in two studies [, ], hs-CRP in one study [] with male subjects only, TNF-α in two studies [, ], and IL-10 in one study [].；Nonetheless, two studies involving participants of both biological sexes and investigating simultaneously three or more inflammation biomarkers did not report any statistically significant differences [, ]. ‖ 结论：The findings highlight the potential role of inflammatory biomarkers in PP decline and underscore the need for further research exploring the interactions among age, sex, comorbidities, and inflammatory pathways.
局限
However, given the cross-sectional nature of the included studies, it remains unclear whether elevated inflammatory biomarkers precede or result from reduced PP.；Jones and colleagues [] observed an association between the lower limb’s muscle dysfunction and several biomarkers, however, due to the lack of standardized sarcopenia diagnostic criteria no direct comparisons could have been made.；Importantly, the lack of studies in other PP parameters does not necessarily exclude them for their potential association, but it rather emphasizes the need for future studies to better comprehend these pathways.
对本项目的价值
★☆☆☆☆ 衰弱/肌少症是少有的已有监管认可终点的老年综合征，是临床转化的最短路径。设计 cross-sectional。
全文来源
PMC JATS 全文（正文 32,531 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：What is the impact of CRP, hs-CRP, IL-6, IL-10, and TNFα in physical performance in community-dwelling older adults: a systematic review.
- 期刊与标识：BMC Geriatr · PMID 42947014 · DOI 10.1186/s12877-026-08080-8
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