时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
Additionally, a “leave-one-out” sensitivity analysis was conducted to assess whether any single SNP could introduce bias affecting the overall causal conclusions.
方法
Our research involved human subjects and was a reanalysis of existing publicly available data that had already received ethical approval and participant consent, thereby eliminating the need for additional ethical review or consent procedures.；These phenotypes comprised TBNK cells, regulatory T cells (Treg), dendritic cells, monocytes, and myeloid populations.Endometriosis: Genome-wide association study (GWAS) data were sourced from the FinnGen consortium’s R11 release dataset (https://r11.finngen.fi/), comprising 18260 case samples and 119468 control samples, all of which were of European ancestry.15.；In our analysis, gut microbiota and immune cell metrics were modeled as continuous exposures, whereas endometriosis was analyzed as a binary outcome.Instrumental Variables SelectionInstrumental variables (IVs) were chosen adhering to the three fundamental assumptions of Mendelian randomization (MR): (1)Relevance: IVs must demonstrate a robust association with gut microbiota (p < 5×10−8; if fewer than 10 SNPs were available, p < 1×10−5).
核心结论
In our analysis, gut microbiota and immune cell metrics were modeled as continuous exposures, whereas endometriosis was analyzed as a binary outcome.Instrumental Variables SelectionInstrumental variables (IVs) were chosen adhering to the three fundamental assumptions of Mendelian randomization (MR): (1)Relevance: IVs must demonstrate a robust association with gut microbiota (p < 5×10−8; if fewer than 10 SNPs were available, p < 1×10−5).；Paceibacteria demonstrated the most substantial protective magnitude (OR = 0.46, 95% CI: 0.26–0.80; p = 0.0056), but this estimate was characterized by broader confidence intervals (Figure 2).；Similarly, V9D3004 demonstrated a significant positive association (OR = 1.1229, 95% CI: 1.0064–1.2528; p = 0.0380) based on 18 genetic variants.
局限
While statistical rigor is paramount, the potential impact of missing data on our conclusions warrants careful consideration.；Comprehending these multifaceted interactions is vital for developing comprehensive treatment protocols.This study acknowledges certain limitations.；Given the intricate interplay within the GBA involving hormonal and psychological dimensions, more refined investigative approaches are warranted.
对本项目的价值
中高价值：属「微生物组及其代谢物干预」方向；微生物组及其代谢物干预栏目可用作本项目文献库与综述素材。 ｜ 价值分 3.0/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 28,837 字符，题名指纹 1.0，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：免疫细胞介导的肠道菌群与子宫内膜异位症互作：孟德尔随机化研究
- 英文标题：Immune Cell-Mediated Interactions Between the Gut Microbiome and Endometriosis: A Mendelian Randomization Investigation.
- 期刊与标识：International journal of women's health · PMID 42974072 · DOI 10.2147/IJWH.S553605 · PMC PMC13725086