时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
Our aim was to describe how gastric cancer burden varies across populations and ages, and how age relates to clinical presentation, competing mortality, and survival at the patient level.2Methods2.1Study designThis was a secondary analysis of two public data sources.
方法
Improvements in prevention, diagnosis, and treatment have reduced age-standardized rates in many settings, yet the absolute number of patients requiring diagnosis, treatment, and long-term care remains large (2, 3).；Gastric cancer is strongly age dependent, but younger patients and older adults raise different clinical questions (5–7).；AYA patients may present with distinctive histology, stage distribution, genetic susceptibility, diagnostic delay, and survivorship needs (5–9).
核心结论
Incident cases and deaths increase overall, whereas DALYs fluctuate and decrease slightly by 2021.；These findings are consistent with previous evidence showing that gastric cancer remains a major global health burden despite declining incidence or mortality rates in many settings (2, 3, 23).The divergence between all-age numbers and age-standardized rates is important for interpretation.；These findings should not be interpreted as evidence that GBD age patterns cause SEER survival differences; the two sources provide complementary evidence from non-interchangeable populations.AYA gastric cancer accounted for a small proportion of SEER cases, but the clinical profile of this group remains important.
局限
These implications should be viewed as direction-setting rather than prescriptive policy recommendations.This study has several strengths and limitations.；Limitations include the modeled nature of GBD estimates, the absence of country-level data in the downloaded GBD dataset, the lack of individual linkage between GBD and SEER, and the limited global generalizability of SEER registry data (4, 14, 15).
对本项目的价值
中等价值：属「衰老机制与老年临床」方向；其他衰老相关栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.6/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 27,122 字符，题名指纹 0.94，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：全球与区域胃癌疾病负担及年龄相关生存差异：GBD 2021 与 SEER 数据互补分析
- 英文标题：Global and regional gastric cancer burden and age-related survival disparities: complementary analyses of GBD 2021 and SEER data.
- 期刊与标识：Frontiers in oncology · PMID 42978639 · DOI 10.3389/fonc.2026.1880227 · PMC PMC13727433