时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
These potential mechanisms provide a rationale for investigating whether GLP-1 RAs may influence reproductive outcomes in addition to their established metabolic effects.；Therefore, the objective of this scoping review is to identify, characterize, and summarize the published literature evaluating reproductive and gynecologic outcomes following treatment with GLP-1 RAs in women with PCOS.
方法
The most common diagnostic criteria, named the Rotterdam criteria, characterize the disease by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology [].；The restrictions placed on study design during the initial search were English-language and peer-reviewed literature.；Studies meeting inclusion criteria based on title and abstract underwent full-text review using the same reviewer assignment process.
核心结论
The disease is frequently associated with and closely linked to obesity, insulin resistance, dyslipidemia, and an increased risk of type 2 diabetes mellitus [].；Several reviews have summarized the metabolic effects of GLP-1 RAs in PCOS [,], but to our knowledge, no scoping review has comprehensively mapped the evidence specifically addressing reproductive and gynecologic outcomes associated with these therapies.；The study must also have reported at least one reproductive or gynecologic outcome, including but not limited to menstrual cyclicity, ovulation, fertility, pregnancy outcomes, hyperandrogenism, ovarian morphology, or reproductive hormone measurements. ‖ 结论：Future high-quality prospective studies with standardized reproductive outcome measures are needed to better define the role of these agents in the management of PCOS.
局限
Although the current evidence is promising, considerable heterogeneity among studies and the frequent coexistence of substantial metabolic improvement make it difficult to determine the extent to which reproductive benefits are directly attributable to GLP-1 RA therapy.
对本项目的价值
★☆☆☆☆ 生殖衰老提供「衰老速率可被激素轴调节」的天然实验窗口。设计 scoping review。
全文来源
PMC JATS 全文（正文 20,206 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Reproductive and Gynecologic Effects of Glucagon-Like Peptide-1 Receptor Agonists in Women With Polycystic Ovary Syndrome: A Scoping Review.
- 期刊与标识：Cureus · PMID 42953685 · DOI 10.7759/cureus.117072
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