时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
Whether exercise-related changes in dynamic functional connectivity (dFC) reflect neural reorganization, vascular effects, or both remains uncertain, and most studies have not tested sex as a moderator.
方法
We propose the Sex-Dependent Dynamic Reconstitution Model (SDDRM) as a hypothesis-generating framework.；We outline four candidate, sex-stratified predictions: (1) sex may moderate exercise-related MTL flexibility changes, with menopausal status as an exploratory moderator; (2) dynamic flexibility changes may partially mediate cognitive improvement, with indirect pathway magnitudes compared using moderated mediation; (3) exercise cessation may produce different flexibility decay trajectories by sex; and (4) exercise modality may interact with sex.；We emphasize dFC methodological caveats—including scan duration, motion, test–retest reliability, and neurovascular coupling—and distinguish biomarker-confirmed AD from MCI and cognitively unimpaired populations.
核心结论
Recent large-scale studies have mapped stage-dependent dynamic network dysfunction across the AD continuum [12], and animal models have demonstrated that physical activity can modulate network-level dynamics in AD-vulnerable circuits [13].；In AD, emerging evidence suggests reduced flexibility, altered variability, and increased state persistence [9–12], but these findings are methodologically heterogeneous and should not be interpreted as evidence that dynamic measures are inherently superior to static measures.；We conclude with testable predictions, challenge conditions, and a research framework.
局限
Keywords: Alzheimer's disease, dynamic functional connectivity, sex differences, exercise intervention, network flexibility, hypothesis-generating framework, methodological limitations 1.；What this static framework obscures, however, is a fundamental property of neural organization: functional connectivity is not stationary but fluctuates dynamically over timescales of seconds to minutes [7].；The neural mechanisms linking exercise to cognitive preservation, however, remain incompletely characterized.
对本项目的价值
中等价值：属「脑老化与神经退行」方向；脑老化 / 神经退行 / 认知栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.6/5（★★★☆☆）
全文来源
出版商/仓储 OA PDF（正文 22,244 字符，题名指纹 1.0，正文内 DOI 命中，已过题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：运动、动态功能连接与性别在阿尔茨海默病中的作用：性别依赖性动态重构模型的假设生成框架
- 英文标题：Exercise, Dynamic Functional Connectivity, and Sex in Alzheimer's Disease: A Hypothesis-Generating Framework for the Sex-Dependent Dynamic Reconstitution Model.
- 期刊与标识：Aging and disease · PMID 42970313 · DOI 10.14336/AD.2026.1096