时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
摘要（PubMed 原文节选）
Intrinsic and extrinsic skin aging are characterized by progressive disruption of redox homeostasis, increased reactive oxygen species (ROS) accumulation, and a gradual decline in skin regenerative and repair capacity. Excessive ROS damages DNA, proteins, and cellular lipids and activates redox-sensitive pathways, including nuclear factor kappa B (NF-κB) and activator protein-1 (AP-1). Oxidative stress also promotes matrix metalloproteinase (MMP) expression, chronic inflammation, and extracellular matrix (ECM) degradation. Human placental extract (HPE) is a complex, heterogeneous biological preparation reported to contain peptides, metabolites, extracellular matrix-derived components, growth…
对本项目的价值
参考价值：属「干细胞 / 部分重编程再生」方向；线粒体功能与氧化应激栏目可用作本项目文献库与综述素材。 ｜ 价值分 1.5/5（★★☆☆☆）
全文不可及原因
无 PMCID 且 OpenAlex / Unpaywall 未提供可下载 OA PDF
原文题录
- 中文题名：冻干人胎盘提取物用于皮肤年轻化：miR-21/miR-141-KEAP1/NRF2 网络新视角
- 英文标题：Emerging perspectives on skin rejuvenation using lyophilized human placental extract: a proposed miR-21/miR-141-KEAP1/NRF2 regulatory network.
- 期刊与标识：Mol Biol Rep · PMID 42965709 · DOI 10.1007/s11033-026-13029-6 · EDAT 2026-10-31