时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
The extent to which the findings from high-income settings can be generalized elsewhere is unclear.；This study therefore examines whether cumulative early life adversity in the first two years of life is associated with internalizing and externalizing behaviors in children across three LMIC cohorts.
方法
The aim of this study was to examine the associations of early life adversity with child internalizing and externalizing behavior at 7–10 years using pooled behavioral data from three low- and middle-income cohorts.；We hypothesized that higher exposure to early life adversity would be associated with greater internalizing and externalizing difficulties across cohorts.；Data were collected from children enrolled in three low- and middle-income country cohorts.；As each cohort conducted assessments at different time points, outcome data from children aged 7–10 years were utilized in this study.
核心结论
Imposing metric invariance constraints significantly worsened the model fit compared to the configural model, χ²(32) = 729.8, p < .001, with TLI decreasing to 0.884.；Further constraining the model to scalar invariance also resulted in a significant decrease in fit relative to the metric model, χ²(32) = 810.1, p < .001, with TLI decreasing to 0.854.；After excluding n = 435 participants due to incomplete or missing data, analyses included n = 708 participants. ‖ 结论：In conclusion, in cohorts from the Global South, while there is an association between early life adversity and psychopathology, there are also important context-dependent differences across cohorts.
局限
As the standardized effect sizes for these associations are relatively small in this study, the findings may not be clinically relevant on an individual level.；The heterogeneity observed across cohorts in the present study suggests that intervention strategies should prioritize locally salient risk factors and leverage existing service platforms, rather than adopting a uniform approach across countries.；First, the adversity variable was heterogeneous between cohorts, therefore, to mitigate heterogeneity in the adversity variable, the adversity variable was dichotomized.
对本项目的价值
★☆☆☆☆ 相关范围内，作为背景与横向对照收录。
全文来源
PMC JATS 全文（正文 35,184 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Association of early life adversity with internalizing and externalizing behavior across 3 low- and middle-income countries.
- 期刊与标识：Child Adolesc Psychiatry Ment Health · PMID 42947136 · DOI 10.1186/s13034-026-01139-9
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。