时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
研究问题
However, despite the promising performance of blood-based biomarkers in distinguishing AD patients from healthy controls, their relationship with clinical heterogeneity remains poorly characterized.；Group comparisons and correlation analyses were designated as primary analyses, while logistic regression and ROC analyses were considered exploratory and hypothesis-generating, with their results requiring cautious interpretation and prospective validation.；3.1.3 Correlation analysis between dementia severity levels and differential indicators in AD This study aims to perform a correlation analysis of significant variables derived from general information and peripheral blood biomarkers in relation to early-stage, moderate, and severe AD.
方法
The SHA-03-W1 four-diagnostic instrument, for instance, captures objective data on tongue appearance, pulse waveforms, and facial complexion, and integrates image processing with data-mining techniques to enable quantitative analysis of TCM syndromes ( Ren et al., 2020 ).；Moreover, it will provide empirical evidence that may refine the hypothesized “Kidney deficiency → Phlegm-stasis → Heat-toxin” distribution pattern within a cross-sectional AD sample.；This cohort includes both inpatient and outpatient individuals.
核心结论
Among the TCM syndrome elements, phlegm stagnation was significantly associated with moderate AD (OR = 1.198, 95% CI 1.079–1.329, p = 0.001) and showed a consistent but non-significant trend toward severe AD (OR = 1.200, 95% CI 0.983–1.464, p = 0.073).；Heat toxin was significantly associated with both moderate and severe AD, with a stronger effect observed in the severe group (moderate: OR = 1.177, 95% CI 1.046–1.324, p = 0.007; severe: OR = 1.498, 95% CI 1.205–1.861, p < 0.001).；Kidney deficiency was not significantly associated with either comparison ( p = 0.710 and p = 0.292, respectively).
局限
However, despite the promising performance of blood-based biomarkers in distinguishing AD patients from healthy controls, their relationship with clinical heterogeneity remains poorly characterized.；(4) Potential participants were excluded if investigators determined they were unable to comply with study requirements.
对本项目的价值
中等价值：属「脑老化与认知轨迹」方向；脑老化 / 神经退行 / 认知栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.4/5（★★☆☆☆）
全文来源
PubMed PMC JATS（正文 51,950 字符，题名指纹 0.94，已过 DOI 逐字 + 题名指纹 + 正文长度三重归属校验）
原文题录
- 中文题名：肾虚、痰瘀、热毒证型与阿尔茨海默病严重度的横断面关联探索
- 英文标题：Cross-sectional associations of Kidney deficiency, Phlegm-stasis, and Heat-toxin syndrome patterns with disease severity in Alzheimer's disease: an exploratory study.
- 期刊与标识：Front Aging Neurosci · PMID 42964118 · DOI 10.3389/fnagi.2026.1763273 · PMC PMC13719365 · EDAT 2026-10-31