时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
研究问题
Most trans-modal imaging models of AD-type tau propagation and neurodegeneration have relied on network-based frameworks, commonly referred to as the “prion-like” spreading hypothesis2 .；7 Department of Information Technology, Mayo Clinic Rochester, Rochester, MN, USA. *A full list of members and their affiliations appears in the Supplementary Information. e-mail: jones.david@mayo.edu Nature Communications Article in Press 1234567890():,; 1234567890():,; hypothesis posits that functional and structural brain networks pro- vide conduits through which pathogenic proteins propagate.；It has also been suggested that the prion-like spreading hypothesis, while informative, may provide only a partial mechanistic account of tau propagation and neurodegeneration16 .
方法
Validation was conducted in: (1) a longitudinal subset of the training cohort (n = 215), (2) Alzheimer’s Disease Neuroimaging Initiative (n = 295), and (3) a heretogeneous clinical cohort (n = 264; n = 28 with FTP-PET).；It performed well in clinical scenarios, including classification of low versus high tau stages (79–95% accuracy) and prediction of tau in a heterogeneous clinical cohort without FTP-PET.；3 Department of Quantitative Health Sciences, Mayo Clinic Rochester, Rochester, MN, USA.
核心结论
（原文未给出可直接抽取的对应表述）
局限
However, these studies are most often designed to simulate tau propagation dynamics at the region-level and typically not inten- ded to be applied at the participant-level.；However, in order to explicitly assess performance across sexes, R2 values from the main model were compared between males and females across the Schaefer-400 atlas.
对本项目的价值
中等价值：属「脑老化与认知轨迹」方向；脑老化 / 神经退行 / 认知栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.5/5（★★☆☆☆）
全文来源
出版商/仓储 OA PDF（正文 85,900 字符，题名指纹 1.00，已过 DOI 逐字 + 题名指纹 + 正文长度三重归属校验）
原文题录
- 中文题名：预测阿尔茨海默病及相关疾病 tau 分布的大脑功能模型
- 英文标题：A model of brain function to predict tau across Alzheimer's disease and related disorders.
- 期刊与标识：Nat Commun · PMID 42967904 · DOI 10.1038/s41467-026-78300-7 · EDAT 2026-11-01