时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
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摘要（PubMed 原文节选）
BACKGROUND: Chemotherapy-induced central neurotoxicity (CICN), commonly known as "chemo-brain", is a prevalent and debilitating condition in cancer survivors, characterized by persistent cognitive deficits that severely compromise quality of life. Despite extensive research, the pathophysiology of CICN remains fragmented, lacking a unifying model that explains how it progresses from peripheral insult to chronic cognitive consolidation. AIM OF REVIEW: This review proposes a novel Three-Hit sequential model to reconceptualize CICN as a dynamic, staged pathological continuum. Unlike existing multi-hit hypotheses that largely describe cumulative or concurrent CNS risk factors, the Three-Hit mode…
对本项目的价值
中等价值：属「衰老细胞清除 / SASP 轴」方向；脑老化 / 神经退行 / 认知栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.6/5（★★★☆☆）
全文不可及原因
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原文题录
- 中文题名：化疗脑的三打击序贯模型：从外周炎症到中枢氧化应激与突触功能障碍
- 英文标题：A three-hit sequential model of chemo-brain: from peripheral inflammation to central oxidative stress and synaptic dysfunction.
- 期刊与标识：J Adv Res · PMID 42966467 · DOI 10.1016/j.jare.2026.10.052 · EDAT 2026-10-31