时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
研究问题
3 Methods (Differential Diagnosis, Investigations, and Treatment) 3.1 Differential Diagnosis and Investigations To investigate the unexplained and severe cholestasis, a diagnostic liver biopsy was performed.
方法
3 Methods (Differential Diagnosis, Investigations, and Treatment) 3.1 Differential Diagnosis and Investigations To investigate the unexplained and severe cholestasis, a diagnostic liver biopsy was performed.
核心结论
We report a complex case of aggressive hepatic AL amyloidosis emerging during the biochemical progression of IgG lambda MM in a patient with a history of severe steroid‐induced psychosis.；Severe cholestatic jaundice remains an uncommon and catastrophic presentation of hepatic amyloidosis, but our data show that immediate clone‐directed therapy can drive rapid mechanical and functional organ reversal [ 7 , 8 , 9 ].
局限
However, 3 days later, he was urgently hospitalized for fever, severe asthenia, and dyspnea.
对本项目的价值
参考价值：属「衰弱 / 肌少症功能结局」方向；脑老化 / 神经退行 / 认知栏目可用作本项目文献库与综述素材。 ｜ 价值分 1.9/5（★★☆☆☆）
全文来源
PubMed PMC JATS（正文 9,903 字符，题名指纹 0.95，已过 DOI 逐字 + 题名指纹 + 正文长度三重归属校验）
原文题录
- 中文题名：侵袭性肝 AL 型淀粉样变遭遇治疗性衰弱：达雷妥尤单抗方案的快速器官逆转
- 英文标题：Aggressive Hepatic AL Amyloidosis Encountering Therapeutic Frailty: Rapid Organ Reversal With Tailored Daratumumab-Based Therapy and Low-Dose Corticosteroids in a Patient With Steroid-Induced Psychosis.
- 期刊与标识：Clin Case Rep · PMID 42964457 · DOI 10.1002/ccr3.73831 · PMC PMC13719798 · EDAT 2026-10-31