时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
One major clinical challenge is that PACG is often diagnosed only after significant structural and functional damage has occurred [].；These observations raise the question of whether the pathological environment of persistent IOP elevation in glaucoma, in turn, promotes lens-related pathologies and thereby reinforces the pathogenic cycle of PACG.；Despite this biological relevance, the protein landscape of the human ALC in PACG remains largely undefined [].
方法
The study adhered to the principles outlined in the Declaration of Helsinki and was approved by the Ethics Committee of Xiangya Hospital, Central South University, China (approval no. 2025111924).；This study was registered with the Chinese Clinical Trial Registry under registration number ChiCTR2600124069, and written informed consent was obtained from all participants prior to the study initiation.；Participants were divided into two groups: patients with ARC alone (ARC group) and patients with ARC combined with PACG (PACG group).；The inclusion criteria for both ARC group and PACG groups were as follows: (1) age 50–90 years old; (2) bilateral age-related cataracts (less than grade 5 Lens Opacities Classification System, version III); (3) scheduled for phacoemulsification and intraocular lens (IOL) implantation or combined phacotrabeculectomy.
核心结论
No significant differences were observed between the two groups in age (67.15 ± 8.16 vs. 68.80 ± 8.77 years, P = 0.647), sex (4/9 vs. 5/5, P = 0.417), uncorrected visual acuity (1.01 ± 0.85 vs. 0.93 ± 0.88 logMAR, P = 0.822), best-corrected visual acuity (0.83 ± 0.92 vs. 0.61 ± 0.96 logMAR, P = 0.593), axial length (23.25 ± 1.06 vs. 23.07 ± 0.94 mm, P = 0.688), corneal endothelial cell density (2773.02 ± 221.60 vs. 2421.82 ± 591.42 cells/mm², P = 0.074), or lens thickness (4.73 ± 0.41 vs. 4.94 ± 0.19 mm, P = 0.156).；In contrast, the PACG group showed significantly higher IOP (16.70 ± 4.47 vs. 12.92 ± 2.30 mmHg, P = 0.020) and a significantly shallower anterior chamber depth (2.29 ± 0.43 vs. 2.87 ± 0.87 mm, P = 0.004) than the ARC group.；Together, these findings reveal broad proteomic alterations in ALCs from PACG compared with ARC controls. ‖ 结论：By integrating local tissue proteomics with experimental validation, PBMC-based peripheral support, and exploratory population-level plasma analysis, this work extends current understanding of PACG beyond anatomy and highlights the lens-associated microenvironment as a relevant molecular context in disease.
局限
Thus, elevated IOP may not only result from angle closure but may also adversely affect the lens-associated microenvironment, potentially creating a pathological cycle involving LEC dysfunction, cataract progression, and worsening anterior segment crowding.；The positive association of CRYBB2 suggests that lens-associated molecular alterations in glaucoma may not be fully restricted to the local ALC environment.；Although preliminary and limited by sample size, this finding supports the notion that ATP6V1A-associated alterations may be more readily captured in nucleated cellular compartments than in plasma.
对本项目的价值
★☆☆☆☆ 营养感知与自噬轴决定「干预窗口 + 剂量方案」，是组合疗法的时间锚。队列：UK Biobank、UKB。
全文来源
PMC JATS 全文（正文 54,713 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Comparative proteomics of human anterior lens capsules reveals ATP6V1A-associated lysosomal dysregulation in age-related cataract with primary angle-closure glaucoma.
- 期刊与标识：J Transl Med · PMID 42947198 · DOI 10.1186/s12967-026-08934-0
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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