时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
He considered the absence of recurrent blistering reassuring but remained dissatisfied with the control of psoriasis.Because he did not attend regular follow-up visits, objective post-treatment psoriasis scores and repeat measurements of eosinophils, total immunoglobulin E, BP180 and BP230 antibodies, and direct immunofluorescence findings were unavailable.
方法
A systematic review and a population-based cohort study demonstrated an increased and bidirectional association between the two diseases (1, 2).；We report more than two years of follow-up after BP developed during secukinumab therapy.；This extended clinical course provides insight into the selection of subsequent targeted therapies and the dissociation between clinical and immunological remission in patients with coexisting psoriasis and BP.Case descriptionA 68-year-old man with a more than 20-year history of plaque psoriasis presented to our department in March 2023 because of extensive and poorly controlled skin lesions.
核心结论
A systematic review and a population-based cohort study demonstrated an increased and bidirectional association between the two diseases (1, 2).；Panel F demonstrates negative immunofluorescence findings at one hundred times magnification.Diagnostic assessmentLaboratory investigations revealed a white blood cell count of 13.80 × 109/L and an absolute neutrophil count of 8.50 × 109/L.；Histopathological examination of a lesional skin biopsy demonstrated a subepidermal cleft and blister formation, with infiltration of eosinophils, neutrophils, and lymphocytes in the superficial dermis.
局限
However, newly developed eczematous lesions subsequently appeared.；However, no typical tense vesicles or bullae were observed, and BP was considered to be in clinical remission (Figure 2).Figure 2Clinical, histopathological, and immunopathological findings during follow-up in June 2025.；Close observation was warranted because new-onset BP shortly after deucravacitinib initiation has recently been reported (12).
对本项目的价值
中等价值：属「免疫衰老与慢性炎症」方向；免疫 / 炎症与衰老栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.6/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 23,786 字符，题名指纹 1.0，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：病例报告：斑块状银屑病司库奇尤单抗治疗中出现大疱性类天疱疮：治疗挑战与长期随访
- 英文标题：Case Report: bullous pemphigoid during secukinumab treatment for plaque psoriasis: therapeutic challenges and long-term follow-up.
- 期刊与标识：Frontiers in immunology · PMID 42978821 · DOI 10.3389/fimmu.2026.1964020 · PMC PMC13727594