时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
However, dysbiosis accompanied by expansion of succinate-producing or succinate-associated taxa, such as Bacteroides or Prevotella, can lead to the accumulation of unconsumed succinate (, ).；However, it remains unclear whether gut microbial composition is associated with circulating succinate levels in AD, and whether modulating the gut microbiota is accompanied by changes in circulating succinate and in cutaneous and systemic inflammatory phenotypes.；Here, we investigated whether preventive administration of B. lactis HEM20-01 (KCTC14143BP) attenuates the development of house dust mite (HDM)-induced AD-like phenotypes.
方法
All procedures were approved by the Institutional Animal Care and Use Committee of CHA University (IACUC-230037) and performed in accordance with institutional guidelines.；Four-week-old male NC/Nga and C57BL/6 mice were purchased from Orient Bio Inc.；Groups were NOR, AD and AD+HEM20-01 (n = 9 each).；C57BL/6 mice received sodium succinate dibasic hexahydrate (Sigma-Aldrich, St.
核心结论
HDM-treated NC/Nga mice exhibited increased modified SCORAD index, transepidermal water loss (TEWL), and scratching behavior, accompanied by epidermal hyperplasia and mast cell infiltration.；Oral HEM20–01 significantly attenuated the development of these clinical and histological features, as evidenced by reductions in modified SCORAD index, TEWL, scratching behavior, epidermal thickness, and mast cell infiltration ().；Consistent with these transcriptional changes, HEM20–01 also reduced the elevated protein levels of IL-4, CCL11, IL-1β, IL-33, IL-17A, and TNF-α in AD-like skin (). ‖ 结论：Collectively, these findings implicate circulating succinate in AD-associated inflammation and show that preventive HEM20–01 administration attenuates this phenotype.
局限
Therefore, a modest shift in luminal production may alter systemic exposure without a detectable change in fecal content, although limited sensitivity or statistical power of the fecal measurement cannot be excluded.；Further studies are required to determine whether these behavioral differences are secondary to reduced overall disease severity or involve metabolic signals such as circulating succinate.；Several limitations of this study should be considered.
对本项目的价值
★☆☆☆☆ 菌群是可远程部署、成本最低的干预变量，但因果性与个体化响应仍是主要瓶颈。
全文来源
PMC JATS 全文（正文 25,081 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Preventive administration of Bifidobacterium animalis subsp. lactis HEM20-01 attenuates the development of atopic dermatitis-like inflammation in mice, along with gut microbial and succinate alterations.
- 期刊与标识：Front Immunol · PMID 42947750 · DOI 10.3389/fimmu.2026.1915780
B 级证据分级：B 级（同行评议临床前研究，主要为动物模型）
本文核心结论来自动物模型或体外细胞学，属临床前证据，不能外推至人体。「延长健康寿命」「改善功能」等表述在小鼠中的意义，与人类临床结局之间仍有距离。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。