时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
By adopting this framework, we aim to highlight both established mechanisms and key knowledge gaps in afferent renal signalling. 2.
方法
We describe the anatomical distribution of efferent and afferent nerves within the nephrons, map the kidney-to-brain signal transmission, describe known molecular pathways, and examine the implications of altered renal afferent signalling in kidney-related comorbidities, including neurological disorders.；We shed light on the therapeutic potential of targeting renal sensory nerves to mitigate renal and neurological decline in the context of an ageing global population.；Most patients live in low-income and lower-middle-income countries, and a large proportion of them lack access to kidney disease diagnosis and treatment.
核心结论
Since TRPV1 is essential for signal propagation and is often co-expressed with CGRP, these results imply that the molecular basis of mechanosensation modalities of afferent renal nerves is yet to be clarified.；However, these results need to be carefully considered due to apparent non-specific binding [45].
局限
However, the exact local renal mechanisms and their broader pathological implications remain to be fully elucidated.；However, a study showed that wild-type and TRPV1-KO mice exhibited comparable responses to elevated pelvic pressure [45].；However, these results need to be carefully considered due to apparent non-specific binding [45].
对本项目的价值
中等价值：属「免疫衰老与慢性炎症」方向；免疫 / 炎症与衰老栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.7/5（★★★☆☆）
全文来源
出版商/仓储 OA PDF（正文 22,582 字符，题名指纹 1.0，正文内 DOI 命中，已过题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：肾脏传入神经拓展健康与疾病中肾-脑轴的图景
- 英文标题：Afferent Renal Nerves Extend the Landscape of the Kidney-Brain Axis in Health and Disease.
- 期刊与标识：Aging and disease · PMID 42970315 · DOI 10.14336/AD.2026.0632