时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
However, the combined impact of these factors on the regulation of autophagic flux in a living tumor microenvironment remains unexamined.；Furthermore, their specific influence on autophagic flux dynamics has not been systematically characterized in an appropriate in vivo Erlich model to address this gap effectively.
方法
We conducted our experiment on 40 female BALB/c mice (8–9 weeks old, weighing 31–35 g), maintained under standard temperature conditions with a regular 12-h light/12-h dark cycle.；The Research Ethics Committee of the Faculty of Science, Capital University, approved the experimental protocol under Approval No.；The mice were randomly assigned to five treatment groups (n = 8/group) using a computer-generated randomization sequence (Random Allocation Software version 2.0).；All biochemical and molecular data are expressed as mean ± SEM with n = 7 per group.
核心结论
The bands associated with the asymmetric and symmetric stretching vibrations of the carboxylate (COO−) groups are observed between 1,621 cm-1 and 1,423 cm-1 in both samples, attributable to the uronic acid residues within the ulvan structure.；The Zeta potential study () indicated that the ulvan-SeNPs exhibit a significant negative surface charge of −31.7 ± 1.5 mV.；As shown in , treatment with NaSe, Ulvan, NanoSe, and CP resulted in significant (p < 0.05) reductions in tumour growth compared with the Control group. ‖ 结论：In conclusion, ulvan has been unveiled as a promising, natural, and safe anticancer agent with the ability to appropriately modulate all important biological processes involved in tumor growth.
局限
The limitations are the requirement for future studies of autophagic flux and the analysis of the immune cells.
对本项目的价值
★☆☆☆☆ 相关范围内，作为背景与横向对照收录。
全文来源
PMC JATS 全文（正文 46,213 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Harnessing marine polysaccharides for breast cancer therapy: ulvan synergizes with nano-selenium to induce programmed cell death through dual modulation of autophagy and apoptosis.
- 期刊与标识：Front Pharmacol · PMID 42952764 · DOI 10.3389/fphar.2026.1968903
B 级证据分级：B 级（同行评议临床前研究，主要为动物模型）
本文核心结论来自动物模型或体外细胞学，属临床前证据，不能外推至人体。「延长健康寿命」「改善功能」等表述在小鼠中的意义，与人类临床结局之间仍有距离。
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