时间标签：数据日期 2026-11-01 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31–2026/11/01 ｜ 情报发生日期 2026-11-01
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
研究问题
Atrial fibrillation (AF) and type 2 diabetes mellitus (T2DM) are associated with cognitive decline, but possible sex-related differences in cognitive and functional outcomes remain uncertain.
方法
Logistic regression was used to evaluate factors associated with severe cognitive impairment, defined as MMSE <24, in the overall cohort and separately in male and female patients.；Increasing age and higher diastolic blood pressure were associated with higher odds of MMSE <24 in the overall cohort and in sex-stratified analyses.
核心结论
Atrial fibrillation (AF) and type 2 diabetes mellitus (T2DM) are associated with cognitive decline, but possible sex-related differences in cognitive and functional outcomes remain uncertain.；Logistic regression was used to evaluate factors associated with severe cognitive impairment, defined as MMSE <24, in the overall cohort and separately in male and female patients.；Increasing age and higher diastolic blood pressure were associated with higher odds of MMSE <24 in the overall cohort and in sex-stratified analyses.；Higher GDS-15 scores were associated with increased odds of severe cognitive impairment in both sexes, whereas greater functional independence, reflected by higher ADL scores, was associated with lower odds of MMSE <24.
局限
（原文未给出可直接抽取的对应表述）
对本项目的价值
人群纵向证据，可用于假说生成与终点选择：血管老化是全身衰老的先行指标，可与其他时钟做交叉验证。 ｜ 价值分 1.6/5（★★☆☆☆）
全文来源
未取到全文 → 本卡为摘要级解读，未核验全文
原文题录
- 英文标题：A Comparative Exploratory Study of Cognitive and Functional Outcomes by Sex and Age in Patients With Type 2 Diabetes Mellitus and Atrial Fibrillation.
- 期刊与标识：In vivo (Athens, Greece) · PMID 42957253 · DOI 10.21873/invivo.14473
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」（SOP §4.2 摘要级）撰写，依据期刊公开摘要与 PubMed 元数据；付费墙全文未获取之处已标注「待补全文」，未做任何数值推算补全。