时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
摘要（PubMed 原文节选）
Cardiac aging is a major determinant of cardiovascular morbidity and mortality, characterized by progressive myocardial fibrosis, impaired contractile function, vascular dysfunction, and reduced regenerative capacity. Although mitochondrial dysfunction, cellular senescence, and chronic inflammation are recognized hallmarks of cardiac aging, the upstream molecular events that coordinate these processes remain incompletely understood. Emerging evidence suggests that endogenous repetitive genomic elements, particularly Long Interspersed Nuclear Element-1 (LINE-1), function as critical regulators of age-associated inflammatory responses. LINE-1 elements are normally maintained in a transcription…
对本项目的价值
中等价值：属「衰老细胞清除 / SASP 轴」方向；血管 / 心血管老化栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.6/5（★★★☆☆）
全文不可及原因
无 PMCID 且 OpenAlex / Unpaywall 未提供可下载 OA PDF
原文题录
- 中文题名：苏醒的隐秘基因组：LINE-1 逆转座子作为心脏衰老与炎症的新兴调控者
- 英文标题：The Hidden Genome Awakens: LINE-1 Retrotransposons as Emerging Regulators of Cardiac Aging and Inflammation.
- 期刊与标识：QJM · PMID 42968377 · DOI 10.1093/qjmed/hcag309 · EDAT 2026-11-02