时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
Whether the ferroptosis, pyroptosis, and necroptosis pathways proposed in preclinical studies are predominant in human AKI has not been confirmed.Based on these limitations, future research could focus on the following areas, which are similar to the recommendations made by Wang et al.
方法
Single-cell sequencing studies have confirmed that renal tubular epithelial cells, due to their high metabolic activity, are particularly sensitive to ischemia and hypoxia and are more prone to undergoing PCD (6).；However, other studies report a different result for recombinant human erythropoietin (rHuEPO): although it modulates macrophage function, it failed to improve the severity of I/R-AKI, functional recovery, or survival in mice.；Caspase-3-deficient mice exhibit severe tubular injury in the early stage of AKI, suggesting that when apoptosis is inhibited, cells shift toward alternative death pathways such as pyroptosis or necroptosis, thereby causing more severe tissue damage (38, 39).
核心结论
Collectively, these events activate programmed cell death (PCD) pathways, culminating in the “secondary insult” that defines renal tissue damage.；Notably, different forms of PCD do not exist independently but interact to form a network, generating a hybrid mode of cell death that collectively regulates the progression of renal injury.；Numerous studies have demonstrated that inhibition of ER stress can effectively reduce apoptosis and thereby alleviate I/R injury (30–32).
局限
However, due to frequent clinical underdiagnosis, insufficient treatment, and the expanding elderly population, the true burden of AKI may be substantially underestimated (3–5).；However, a compound-centered, parallel narrative fails to reveal the principles governing crosstalk among the individual death pathways, nor does it capture how the metabolic state dictates the selection of a given death modality.；However, other studies report a different result for recombinant human erythropoietin (rHuEPO): although it modulates macrophage function, it failed to improve the severity of I/R-AKI, functional recovery, or survival in mice.
对本项目的价值
中高价值：属「干细胞 / 部分重编程与再生」方向；干细胞 / 再生 / 重编程栏目可用作本项目文献库与综述素材。 ｜ 价值分 3.1/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 53,130 字符，题名指纹 0.89，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：靶向免疫-细胞死亡轴：中药治疗缺血再灌注急性肾损伤的多参数网络方法
- 英文标题：Targeting the immunity-cell death axis: a multi-parametric network approach of traditional Chinese medicine against ischemia-reperfusion acute kidney injury.
- 期刊与标识：Frontiers in immunology · PMID 42974128 · DOI 10.3389/fimmu.2026.1976812 · PMC PMC13726519