时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
Together, these findings suggest that SYW-containing serum attenuates t-BHP-induced oxidative stress and mitochondrial dysfunction in C2C12 cells.3.6PGC-1α-related signaling is associated with the protective effects of SYW in C2C12 myoblastsTo further examine whether PGC-1α-related signaling was involved in the cellular effects of SYW, C2C12 cells were treated with SR18292, a pharmacological inhibitor of PGC-1α-related signaling.
方法
Using SAMP8 mice and t-BHP-treated C2C12 cells, we evaluated the effects of SYW on muscle phenotype, mitochondrial ultrastructure, mitochondrial function, antioxidant responses, and their association with PGC-1α-related signaling.；The dosage range was established based on preliminary dose-screening experiments and body surface area conversion from the conventional clinical dosage.2.2Animals and treatmentsTen 3-month-old male senescence-accelerated mouse resistant 1 (SAMR1) SPF mice and forty age-matched senescence-accelerated mouse prone 8 (SAMP8) SPF mice were obtained from Huafukang Biotechnology (Beijing, China).；At 8 months of age, hindlimb muscle volume, forelimb grip strength and rotarod performance were assessed to verify sarcopenia-like changes in SAMP8 mice.
核心结论
Experimental evidence indicates that Panax ginseng can improve muscle performance,21,22 whereas the roles of Dioscorea opposita Thunb and Atractylodes Rhizoma in age-related skeletal muscle degeneration remain less clearly defined.；These findings suggest that SYW attenuates fibrosis and partially modulates atrophy-related molecular alterations in aging skeletal muscle.3.3SYW improved mitochondrial ultrastructure and mitochondrial function in skeletal muscleGiven the crucial role of mitochondrial dysfunction in sarcopenia, we next examined mitochondrial ultrastructure and function in skeletal muscle.；Together, these findings suggest that SYW partially improves mitochondrial ultrastructure and function in aging skeletal muscle, accompanied by changes in PGC-1α-related signaling.3.4SYW modulated mitochondrial dynamics and antioxidant responses in skeletal muscleConsistent with the mitochondrial ultrastructural observations, SYW partially restored the expression of the fusion-related proteins Mfn1 and Mfn2 in skeletal muscle from SAMP8 mice, whereas OPA1, Drp1, and Fis1 showed more limited changes (Fig. 4A and B).
局限
However, exercise-based strategies may be difficult to implement in frail or mobility-impaired older adults, highlighting the need for complementary interventions that target related biological processes through non-exercise-based mechanisms.；Because the gastrocnemius and soleus differ in fiber-type composition, these muscles were analyzed separately; however, individual fibers were not further classified by fiber type at the TEM level.；However, these pharmacological data do not establish PGC-1α as a single dominant causal mechanism.4DiscussionIn this study, we found that the traditional Chinese medicine formula SYW attenuated sarcopenia-like muscle alterations in an accelerated-aging model by improving mitochondrial function and redox balance.
对本项目的价值
中高价值：属「衰老细胞清除 / SASP 轴」方向；细胞衰老 / senolytics / SASP栏目可用作本项目文献库与综述素材。 ｜ 价值分 3.0/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 39,817 字符，题名指纹 0.92，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：山芋丸减轻 SAMP8 小鼠年龄相关肌肉改变并改善线粒体功能
- 英文标题：Shanyu Wan attenuates age-related muscle alterations in SAMP8 mice with improved mitochondrial function.
- 期刊与标识：Journal of traditional and complementary medicine · PMID 42979010 · DOI 10.1016/j.jtcme.2026.07.002 · PMC PMC13729021