时间标签：数据日期 2026-11-01 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31–2026/11/01 ｜ 情报发生日期 2026-11-01
研究问题
Elucidating the mechanisms by which impaired angiogenesis contributes to sarcopenia is crucial for identifying novel therapeutic strategies.；Although the significance of angiogenesis in muscle health is increasingly acknowledged, studies examining the associations between angiogenesis markers and sarcopenia at the population level remain limited.
方法
All analyses were performed using R software, version 4.1.2 (R Foundation for Statistical Computing, Vienna, Austria).；For continuous variables, those conforming to a normal distribution were analyzed via independent Student's t-tests, whereas non-parametric data were evaluated using Wilcoxon rank-sum tests.；Statistical analysis In this study, continuous variables are presented as mean ± standard deviation, while categorical variables are shown as counts with corresponding percentages.
核心结论
Similarly, low ANGPT1 was significantly associated with an increased risk of low ASM and sarcopenia in the univariate analysis, Model 1, and Model 2 (for low ANGPT1 and sarcopenia in Model 2: OR = 3.709, 95% CI: 2.125–6.539, p < 0.001).；Specifically, lower VEGF levels were consistently linked to low HGS, low ASM, and sarcopenia, whereas lower ANGPT1 levels were primarily associated with low ASM and an increased risk of overall sarcopenia.；Research indicates that exercise can lead to increased expression of VEGF in skeletal muscle, which may be associated with the physiological damage to skeletal muscle caused by exercise ( , ).；Furthermore, reduced capillarization in older adults has been clinically correlated with diminished appendicular muscle mass, lowered grip strength, and decreased physical performance ( , ).
局限
This single-center, hospital-based design introduces a potential selection bias and limits the generalizability of our findings to the broader, healthy community-dwelling elderly population.；The cross-sectional design of our study precludes establishing causality or determining the temporal sequence between changes in angiogenesis markers and the development of sarcopenia.
对本项目的价值
人群纵向证据，可用于假说生成与终点选择：功能结局（衰弱 / 肌少症）是临床转化最可及的终点，适合作为一期终点候选。 ｜ 价值分 1.0/5（★☆☆☆☆）
全文来源
PubMed PMC JATS 全文（正文 29,035 字符，已过 DOI 逐字 + 题名指纹双重归属校验）
原文题录
- 英文标题：Relationships between serum angiogenesis markers and sarcopenia: a cross-sectional study.
- 期刊与标识：Frontiers in medicine · PMID 42964051 · DOI 10.3389/fmed.2026.1922045
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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