时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
T-U SRIS activity across fibroblast subpopulations calculated by AUCell and UCell algorithms Given its strong association with the eCAFs phenotype, we sought to determine whether high MFAP2 expression is enriched in a specific cell state along the fibroblast differentiation trajectory.；The coordinated upregulation of this extensive matrix-production program at the differentiation terminus solidifies the identity of MFAP2⁺ eCAFs as a functionally mature subpopulation committed to constructing a pro-invasive, remodeled microenvironment (Fig. 5L).Having established MFAP2 as a core component of the MFAP2⁺ eCAFs transcriptional program, we aimed to validate their spatial co-localization in intact tumor tissues.；Whether this binding has any functional consequences remains to be determined.
方法
Although comprehensive treatment strategies have advanced, patients with advanced disease continue to face challenges, including recurrence, metastasis, and chemoresistance.；The emergence of immune checkpoint inhibitors (ICIs) has recently transformed the treatment landscape for advanced GC, providing renewed hope for some patients [5, 6].；However, responses to ICI therapy vary substantially, with only a subset of patients achieving long-term benefits, whereas many experience primary or acquired resistance [7–9].
核心结论
L-M SRIS activity across cell clusters calculated by AUCell and UCell algorithms Collectively, SRIS established in transcriptomic data demonstrated a significant association with GC progression and poor prognosis.；Taken together, these results defined SRIS, which was prognostic, functionally active, and particularly enriched in CAFs.Evaluation of TME and immune landscape of SRIG-based subtypesConsidering the significance of SRIS in GC, we attempted to elucidate the immunosuppressive state and changes in the TME in GC based on these key genes.；These findings were consistently reinforced by GSEA, which confirmed the upregulation of these pathways in cluster C2 (Fig. 2M).
局限
However, responses to ICI therapy vary substantially, with only a subset of patients achieving long-term benefits, whereas many experience primary or acquired resistance [7–9].；However, bulk RNA sequencing remains fundamental for molecular subtyping and biomarker discovery, and single-cell RNA sequencing (scRNA-seq) provides unprecedented resolution in dissecting cellular heterogeneity and subpopulation dynamics [16].；These integrated findings established MFAP2 as the prime target for further studies.
对本项目的价值
中高价值：属「衰老细胞清除 / SASP 轴」方向；细胞衰老 / senolytics / SASP栏目可用作本项目文献库与综述素材。 ｜ 价值分 3.0/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 66,056 字符，题名指纹 0.93，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：衰老相关免疫抑制基因 MFAP2 调控胃癌基质-免疫串扰与免疫治疗耐药
- 英文标题：Senescence-related immunosuppressive gene MFAP2 orchestrates stromal-immune crosstalk and immunotherapy resistance in gastric cancer.
- 期刊与标识：BMC cancer · PMID 42972272 · DOI 10.1186/s12885-026-16660-5 · PMC PMC13726166