时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
However, despite extensive research, the mechanisms involved in these benefits have not been fully established.
方法
The institutional Animal Research Ethics Committee approved the study under protocol 1271/2018; procedures followed the guidelines of the Brazilian College for Animal Experimentation.；At postoperative week 18, surviving animals underwent transthoracic echocardiography to characterize cardiac injury before allocation to four groups: Sham (n = 15), Sham-Emp (n = 16), AS (n = 26), and AS-Emp (n = 27).；Hematoxylin and eosin staining was used for myocyte morphometry.；For the MDA assay [], serum was combined with 0.67% thiobarbituric acid (TBA) at a 1:1 ratio and heated for 45 min in a 100 °C water bath.
核心结论
All rats were subjected to AS or Sham surgery.；Mortality was statistically lower in AS-Emp than AS (mortality rate: AS 33.3%; AS-Emp 11.1%; Goodman test; p < 0.05).；AS-Emp had a lower percentage of ascites and liver congestion than AS. ‖ 结论：These data highlight SGLT2 inhibition as a potential therapeutic strategy in pressure overload-induced heart failure.
局限
The exclusion of female rats was a limitation in this study.
对本项目的价值
★☆☆☆☆ 血管老化提供可影像量化、可短期读取的中间终点，适合做机制到临床的桥接。最大样本量约 1,078。
全文来源
PMC JATS 全文（正文 31,108 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Effects of SGLT2 inhibition on cardiac remodeling and heart failure development in aortic stenosis rats.
- 期刊与标识：Mol Biomed · PMID 42955596 · DOI 10.1186/s43556-026-00642-x
B 级证据分级：B 级（同行评议临床前研究，主要为动物模型）
本文核心结论来自动物模型或体外细胞学，属临床前证据，不能外推至人体。「延长健康寿命」「改善功能」等表述在小鼠中的意义，与人类临床结局之间仍有距离。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。