时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
In particular, no previous study has examined whether RR‐r modulates the AGE‐RAGE signaling axis in the context of UVB‐induced skin damage.；Furthermore, in vivo evidence demonstrating its effects on skin morphology and photoaging‐related molecular markers remains limited.；Therefore, the present study aimed to investigate whether RR‐r protects against UVB‐induced skin photoaging in vivo using an HR‐1 hairless mouse model, and to clarify its underlying molecular mechanisms.
方法
After a 1 week acclimation period, the mice were randomly divided into five groups (n = 8 per group): (i) normal control group (UVB non‐irradiated control; NC), (ii) UVB‐irradiated control group (Con), (iii) UVB‐irradiated group administered RR‐r 100 mg/kg/day (R100), (iv) UVB‐irradiated group administered RR‐r at 200 mg/kg/day (R200), and (v) UVB‐irradiated positive control group (Phosphatidylserine, 50 mg/kg/day).；The mice were randomly assigned to groups using a randomized allocation schedule.；All animal experiments were conducted in accordance with the guidelines of the Institutional Animal Care and Use Committee and approved under animal protocol (approval no.；The present study was conducted as an independent experiment within the scope of the approved protocol and in accordance with the Laboratory Animals Welfare Act of Korea and the Korean national laws for animal welfare.
核心结论
As shown in Figure , the body weights of mice did not significantly differ among the groups.；In addition, the serum levels of ALT and AST were not significantly different between the groups (Figure ).；Therefore, the results suggest that the RR‐r extract did not affect by changes in body weight or serum levels of AST and ALT in HR‐1 mice. ‖ 结论：Third, although we demonstrated the modulation of the MAPK/AP‐1 and AGE‐RAGE signaling pathways, additional mechanistic studies are required to establish direct molecular targets.
局限
Despite these promising findings, this study had several limitations.；First, it relied on a single UVB‐induced photoaging model using HR‐1 hairless mice, which may not fully recapitulate the complexity of human skin aging.；Future studies should focus on characterizing the active compounds and confirming their efficacy and safety in human models before their practical application as functional foods or cosmeceutical ingredients.
对本项目的价值
★☆☆☆☆ 皮肤是唯一可直接局部给药、可活检、可影像量化的器官，最快可验证 senotherapeutic 概念。
全文来源
PMC JATS 全文（正文 29,616 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Rosa rugosa Root Extract as a Functional Food Ingredient, Mitigating UVB-Induced Skin Aging Through MAPK/AP-1 and AGE-RAGE Pathway Modulation.
- 期刊与标识：Food Sci Nutr · PMID 42959397 · DOI 10.1002/fsn3.72462
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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