时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
研究问题
Whether rpAD represents a biologically distinct subtype, the extreme end of an AD progression continuum, or a clinically heterogeneous group remains unresolved.；Evidence from general AD, Parkinson’s disease, or Lewy body disease was included only when it informed a clearly labeled hypothesis or co-pathology context.；24 These experiments support a conformational hypothesis, but retrospective sampling, tissue preparation, and disease-stage differences limit causal inference and generalizability.
方法
3 Patients with rpAD may be referred to prion disease surveillance centers as suspected CJD, introducing ascertainment bias into many published cohorts.；We prioritized biomarker-defined or autopsy-confirmed cohorts, comparative clinical studies, and primary mechanistic investigations that specifically included rpAD.；This was not an exhaustive systematic review, and no formal risk-of-bias scoring was performed.
核心结论
34 While these findings demonstrate distinct neuropathological signatures, the cross-sectional nature of post-mortem data precludes determining whether mitochondrial dysfunction precedes, follows, or merely amplifies neuronal injury.
局限
Four overlapping populations should be distinguished: clinically labeled rpAD; rapid cognitive decline during established AD; AD identified during evaluation of a rapidly progressive dementia syndrome; and autopsy-confirmed AD selected for short survival.；4 , 11 The potential contribution of regional differences in genetic background, environmental exposures, and diagnostic criteria warrants further investigation in geographically diverse cohorts.
对本项目的价值
中等价值：属「线粒体质量控制与氧化应激」方向；脑老化 / 神经退行 / 认知栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.4/5（★★☆☆☆）
全文来源
PubMed PMC JATS（正文 37,460 字符，题名指纹 1.00，已过 DOI 逐字 + 题名指纹 + 正文长度三重归属校验）
原文题录
- 中文题名：快速进展型阿尔茨海默病：候选机制与诊断挑战
- 英文标题：Rapidly Progressive Alzheimer's Disease: Candidate Mechanisms and Diagnostic Challenges.
- 期刊与标识：Clin Interv Aging · PMID 42965095 · DOI 10.2147/CIA.S638910 · PMC PMC13721788 · EDAT 2026-10-31